Chemistry:Technetium (99mTc) votumumab
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Short description: Chemical compound
| Monoclonal antibody | |
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| Type | Whole antibody |
| Source | Human |
| Target | tumor antigen CTAA16.88 |
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Technetium (99mTc) votumumab (trade name HumaSPECT) is a human monoclonal antibody labelled with the radionuclide technetium-99m.[1][2] It was developed for the detection of colorectal tumors, but has never been marketed.[3]
The target of votumumab is CTAA16.88, a complex of cytokeratin polypeptides in the molecular weight range of 35 to 43 kDa, which is expressed in colorectal tumors.[4]
References
- ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN)". WHO Drug Information 13 (1). 1999. http://whqlibdoc.who.int/druginfo/INN_1999_list41.pdf.
- ↑ "Radiolabeled Antibody-Based Imaging in Clinical Oncology". Antibody-Drug Conjugates: Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer. Hoboken, New Jersey: John Wiley & Sons. 2017. p. 441. ISBN 978-1-119-06084-0.
- ↑ "Public Statement on HumaSPECT". European Medicines Agency (EMA_. 23 February 2004. http://www.emea.europa.eu/pdfs/human/press/pus/388504en.pdf. "Non-renewal of the marketing authorisation in the European Union"
- ↑ "Summary of Product Characteristics for HumaSPECT". European Medicines Agency (EMA). http://ec.europa.eu/enterprise/sectors/pharmaceuticals/documents/community-register/1998/199809253252/anx_3252_en.pdf.
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