Chemistry:Clobetasol propionate
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| Pronunciation | /kloʊˈbeɪtəsɒl/[1] |
| Trade names | Dermovate, Temovate, Clovate, others |
| AHFS/Drugs.com | Monograph |
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| Routes of administration | Topical |
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| Formula | C25H32ClFO5 |
| Molar mass | 466.97 g·mol−1 |
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Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, and psoriasis.[2] It is applied to the skin as a cream, ointment, or shampoo.[2][3] Use should be short term and only if other weaker corticosteroids are not effective.[3] Use is not recommended in rosacea or perioral dermatitis.[2]
Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia.[2] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome.[2] Use in pregnancy and breastfeeding is of unclear safety.[4] Clobetasol is believed to work by activating steroid receptors.[2] It is a US Class I (Europe: class IV) corticosteroid, making it one of the strongest available.
Clobetasol propionate was patented in 1968 and came into medical use in 1978.[5] It is available as a generic medication.[3] In 2020, it was the 171st most commonly prescribed medication in the United States, with more than 3 million prescriptions.[6][7]
Medical uses
Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis,[8] psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.[9]
Clobetasol propionate is used cosmetically for skin whitening, although this use is controversial. The U.S. Food and Drug Administration has not approved it for that purpose, and sales without a prescription are illegal in the U.S. Nonetheless, skin-whitening creams containing this ingredient can sometimes be found in beauty supply stores in New York City and on the internet. It is also sold internationally, and does not require a prescription in some countries. Whitening creams with clobetasol propionate, such as Hyprogel, can make skin thin and easily bruised, with visible capillaries, and acne. It can also lead to hypertension, elevated blood sugar, suppression of the body's natural steroids, and stretch marks, which may be permanent.[10]
Clobetasol propionate is, along with mercury and hydroquinone, "amongst the most toxic and most used agents in lightening products." Many products sold illegally have higher concentrations of clobetasol propionate than is permitted for prescription drugs.[11]
Contraindications
According to the California Environmental Protection Agency, clobetasol propionate should not be used by pregnant women, or women expecting to become pregnant soon, as studies with rats shows a risk of birth defects:[12]
"Studies in the rat following oral administration at dosage levels up to 50 mcg/kg per day revealed that the females exhibited an increase in the number of resorbed embryos and a decrease in the number of living fetuses at the highest dose. Pregnancy: Teratogenic Effects (i.e., possibility of causing abnormalities in fetuses): Pregnancy Category C: Clobetasol propionate has not been tested for teratogenicity when applied topically; however, it is absorbed percutaneously, and when administered subcutaneously it was a significant teratogen in both the rabbit and mouse. Clobetasol propionate has greater teratogenic potential than steroids that are less potent. There are no adequate and well-controlled studies of the teratogenic effects of clobetasol propionate in pregnant women. Temovate Cream and Ointment should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus."
Forms
Clobetasol propionate is marketed and sold worldwide under numerous names, including Clobex, Clob-x (Colombia), Clovate, Clobet (Biolab Thailand) Clonovate (T.O. Chemicals, Thailand), Cormax (Watson, US), Haloderm (Switzerland, by ELKO Org), Pentasol (Colombia), Cosvate, Clop (Cadila Healthcare, India), Propysalic (India), Temovate (US), Dermovate[13] (GlaxoSmithKline, Canada, Estonia, Pakistan, Switzerland, Portugal, Romania, Israel), Olux, ClobaDerm, Tenovate, Dermatovate (Brazil, Mexico), Butavate, Movate, Novate, Salac (Argentina), and Powercort, Lotasbat and Kloderma (Indonesia), Lemonvate and Clobesol (Italy), Dovate (South Africa), Delor (Ethiopia), Psovate (Turkey), Skineal(Nigeria).
References
- ↑ "Clobetasol Propionate Topical Ointment 0.05% Information". Drug Encyclopedia. Kaiser Permanente. https://members.kaiserpermanente.org/kpweb/drugency/drugdetails.do?drugID=272057.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 "Clobetasol Propionate Monograph for Professionals". American Society of Health-System Pharmacists. https://www.drugs.com/monograph/clobetasol-propionate.html.
- ↑ 3.0 3.1 3.2 British National Formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 1210. ISBN 978-0-85711-338-2.
- ↑ "Clobetasol topical Use During Pregnancy". https://www.drugs.com/pregnancy/clobetasol-topical.html.
- ↑ Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 487. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA487.
- ↑ "The Top 300 of 2020". https://clincalc.com/DrugStats/Top300Drugs.aspx.
- ↑ "Clobetasol - Drug Usage Statistics". https://clincalc.com/DrugStats/Drugs/Clobetasol.
- ↑ "Valacyclovir and topical clobetasol gel for the episodic treatment of herpes labialis: a patient-initiated, double-blind, placebo-controlled pilot trial". Journal of the European Academy of Dermatology and Venereology 23 (3): 263–7. March 2009. doi:10.1111/j.1468-3083.2008.03047.x. PMID 19143902.
- ↑ E. Fougera and Co. "Clobetasol Propionate Cream Usp, 0.05% Clobetasol Propionate Ointment USP, 0.05%". Daily Med. U.S. National Library of Medicine. http://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=994.
- ↑ "Creams Offering Lighter Skin May Bring Risks". January 15, 2010. https://www.nytimes.com/2010/01/16/health/16skin.html.
- ↑ "Mercury, hydroquinone and clobetasol propionate in skin lightening products in West Africa and Canada". Environmental Research 150: 403–410. October 2016. doi:10.1016/j.envres.2016.06.030. PMID 27372064. Bibcode: 2016ER....150..403G.
- ↑ Office of Environmental Health Hazard Assessment (August 22, 1997). "Chemicals Under Consideration For Possible Listing Via The "Formally Required To Be Labeled Or Identified" Mechanism". California Environmental Protection Agency. http://www.oehha.ca.gov/prop65/CRNR_notices/admin_listing/requests_info/referenced_docs/frpkg5r.html.
- ↑ "Dermovate 0.05% W/V Ointment - Clobetasol Topical(0.05% W/V)" (in en-US). Glaxo SmithKline Pharmaceuticals Ltd. GNHIndia.com. https://www.gnhindia.com/products/dermovate-0-05-w-v-ointment-clobetasol-topical0-05-w-v/.
External links
- "Clobetasol propionate". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/clobetasol%20propionate.
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