Biology:MYO5B
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.[1][2][3][4]
Recent evidence suggests that Myosin-Vb is related to the creation of memories[5] by actin-dependent trafficking of AMPA receptor containing recycling endosomes in dendritic spines.[6]
Mutations of MYO5B cause microvillus inclusion disease due to defective trafficking of apical and basolateral proteins.[4]
MYO5B has also been associated with bipolar disorder.[7]
Interactions
MYO5B has been shown to interact with RAB11FIP2.[8]
References
- ↑ "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431–9. Sep 1996. doi:10.1006/geno.1996.0488. PMID 8884266.
- ↑ "Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells". The Journal of Biological Chemistry 282 (32): 23725–36. Aug 2007. doi:10.1074/jbc.M608531200. PMID 17462998.
- ↑ "Entrez Gene: MYO5B myosin VB". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4645.
- ↑ 4.0 4.1 "MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity". Nature Genetics 40 (10): 1163–5. Oct 2008. doi:10.1038/ng.225. PMID 18724368.
- ↑ "DukeHealth.org: Scientists Identify Machinery that Helps Make Memories". http://corporate.dukemedicine.org/news_and_publications/news_office/news/scientists_identify_machinery_that_helps_make_memories.
- ↑ "Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity". Cell 135 (3): 535–48. Oct 2008. doi:10.1016/j.cell.2008.09.057. PMID 18984164.
- ↑ "Whole-genome association study of bipolar disorder". Molecular Psychiatry 13 (6): 558–69. Jun 2008. doi:10.1038/sj.mp.4002151. PMID 18317468.
- ↑ "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry 277 (52): 50415–21. Dec 2002. doi:10.1074/jbc.M209270200. PMID 12393859.
Further reading
- "Molecular cloning and amino acid sequence of brain L-glutamate decarboxylase". Proceedings of the National Academy of Sciences of the United States of America 87 (21): 8491–5. Nov 1990. doi:10.1073/pnas.87.21.8491. PMID 2236059. Bibcode: 1990PNAS...87.8491H.
- "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6549–53. Jul 1994. doi:10.1073/pnas.91.14.6549. PMID 8022818. Bibcode: 1994PNAS...91.6549B.
- "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Research 6 (5): 329–36. Oct 1999. doi:10.1093/dnares/6.5.329. PMID 10574461.
- "Myosin vb is associated with plasma membrane recycling systems". Molecular Biology of the Cell 12 (6): 1843–57. Jun 2001. doi:10.1091/mbc.12.6.1843. PMID 11408590.
- "Identification and characterization of a family of Rab11-interacting proteins". The Journal of Biological Chemistry 276 (42): 39067–75. Oct 2001. doi:10.1074/jbc.M104831200. PMID 11495908.
- "Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling". The Journal of Biological Chemistry 277 (52): 50415–21. Dec 2002. doi:10.1074/jbc.M209270200. PMID 12393859.
- "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research 12 (11): 1773–84. Nov 2002. doi:10.1101/gr.406902. PMID 12421765.
- "Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis". Molecular Biology of the Cell 15 (5): 2456–69. May 2004. doi:10.1091/mbc.E03-09-0706. PMID 15004234.
- "Rab11a and myosin Vb are required for bile canalicular formation in WIF-B9 cells". Proceedings of the National Academy of Sciences of the United States of America 102 (42): 15087–92. Oct 2005. doi:10.1073/pnas.0503702102. PMID 16214890. Bibcode: 2005PNAS..10215087W.
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