Chemistry:ML2-SA1
From HandWiki
Short description: Chemical compound
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| Formula | C14H13Cl2NO |
| Molar mass | 282.16 g·mol−1 |
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ML2-SA1 (EVP-22) is a chemical compound which acts as an "agonist" (i.e. channel opener) for the TRPML2 calcium channel, with high selectivity for TRPML2 and no significant activity at the related TRPML1 and TRPML3 channels. It has been used to demonstrate the role of TRPM2 in immune system function, both triggering release of the chemokine CCL2 from macrophages and stimulating macrophage migration and endolysosomal trafficking.[1][2]
See also
References
- ↑ "Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells". eLife 7. November 2018. doi:10.7554/eLife.39720. PMID 30479274.
- ↑ "TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organelles". Science Advances 6 (46): eabb5064. November 2020. doi:10.1126/sciadv.abb5064. PMID 33177082. Bibcode: 2020SciA....6.5064C.
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