Chemistry:Methylprednisolone suleptanate
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Short description: Chemical compound
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| Trade names | Medrosol, Promedrol |
| Other names | PNU-67590A; U-67590A; Methylprednisolone 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate); 11β,17α-Dihydroxy-6α-methyl-21-((8-(methyl(2-sulfoethyl)amino)-1,8-dioxooctyl)oxy)pregna-1,4-diene-3,20-dione |
| Routes of administration | Intravenous administration |
| Drug class | Corticosteroid; Glucocorticoid |
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| Formula | C33H49NO10S |
| Molar mass | 651.81 g·mol−1 |
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Methylprednisolone suleptanate, sold under the brand names Medrosol and Promedrol, is a synthetic glucocorticoid corticosteroid and a corticosteroid ester—specifically, the C21 suleptanate 21-(8-(methyl-(2-sulfoethyl)amino)-1,8-dioxooctanoate) ester of methylprednisolone.[1][2] It acts as a prodrug of methylprednisolone.[3] Methylprednisolone suleptanate was developed as an improved alternative to methylprednisolone acetate (Depo-Medrol) with greater water solubility for use by intravenous administration.[3]
See also
References
- ↑ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA811.
- ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–. ISBN 978-3-88763-075-1. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA675.
- ↑ 3.0 3.1 "Pilot study of the pharmacokinetics of methylprednisolone after single and multiple intravenous doses of methylprednisolone sodium succinate and methylprednisolone suleptanate to healthy volunteers". J Clin Pharmacol 34 (11): 1109–15. November 1994. doi:10.1002/j.1552-4604.1994.tb01988.x. PMID 7876403.
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