Chemistry:Tiglyl-CoA

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Tiglyl-CoA
Tiglyl-CoA.png
Names
Preferred IUPAC name
[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl (3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-2-methylbut-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-oxobutyl dihydrogen diphosphate
Identifiers
3D model (JSmol)
MeSH tiglyl-coenzyme+A
Properties
C26H42N7O17P3S
Molar mass 849.63 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Tracking categories (test):

Tiglyl-CoA is an intermediate in the metabolism of isoleucine.[1][2] It is an inhibitor of N-acetylglutamate synthetase.[3]

References

  1. ROBINSON WG; BACHHAWAT BK; COON MJ (1956). "TIGLYL COENZYME A AND a-METHYLACETOACETYL COENZYME A, INTERMEDIATES IN THE ENZYMATIC DEGRADATION OF ISOLEUCINE". Journal of Biological Chemistry 218 (1): 391–400. doi:10.1016/S0021-9258(18)65902-2. PMID 13278346. 
  2. "Showing metabocard for Tiglyl-CoA (HMDB02054)". The Metabolomics Innovation Centre (TMIC). http://www.hmdb.ca/metabolites/HMDB02054. 
  3. Coude, F X; Sweetman, L; Nyhan, W L (1979). "Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia". Journal of Clinical Investigation 64 (6): 1544–1551. doi:10.1172/JCI109614. PMID 500823.