Chemistry:Beta-Ketoisocaproic acid

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β-Ketoisocaproic acid
Skeletal formula of beta-ketoisocaproic acid
Preferred IUPAC name
4-Methyl-3-oxopentanoic acid
Other names
4-Methyl-2-oxovaleric acid
3D model (JSmol)
MeSH Beta-ketoisocaproic+acid
Molar mass 130.143 g·mol−1
Density 1.1 g cm−3 (at 20 °C)
Boiling point 236 °C (457 °F; 509 K) ±23 at 760 mmHg
log P 0.36
Corrosive C
R-phrases (outdated) R34
S-phrases (outdated) S26, S36/37/39, S45
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Tracking categories (test):

β-Ketoisocaproic acid is an intermediate in the metabolism of leucine.[1][2] Its metabolic precursor and metabolic product in the leucine metabolic pathway are β-leucine and β-ketoisocaproyl-CoA, respectively.[1]


  1. 1.0 1.1 Nutrient Metabolism: Structures, Functions, and Genes (2nd ed.). Academic Press. May 2015. pp. 385–388. ISBN 978-0-12-387784-0. Retrieved 6 June 2016. "Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds ...
    Figure 8.57: Metabolism of L-LEUCINE"
  2. "Leucine metabolism". Technische Universität Braunschweig. Retrieved 12 August 2016.