|Preferred IUPAC name
3D model (JSmol)
|Molar mass||131.175 g·mol−1|
|GHS Signal word||Warning|
|H315, H319, H335|
|P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405, P501|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
β-Leucine (beta-leucine) is a beta amino acid and positional isomer of L-leucine which is naturally produced in humans via the metabolism of L-leucine by the enzyme leucine 2,3-aminomutase. In cobalamin (vitamin B12) deficient individuals, plasma concentrations of β-leucine are elevated.
Biosynthesis and metabolism in humans
A small fraction of L-leucine metabolism – less than 5% in all tissues except the testes where it accounts for about 33% – is initially catalyzed by leucine aminomutase, producing β-leucine, which is subsequently metabolized into β-ketoisocaproate (β-KIC), β-ketoisocaproyl-CoA, and then acetyl-CoA by a series of uncharacterized enzymes.
- Nutrient Metabolism: Structures, Functions, and Genes (2nd ed.). Academic Press. May 2015. pp. 385–388. ISBN 978-0-12-387784-0. https://books.google.com/books?id=aTQTAAAAQBAJ. Retrieved 6 June 2016. "Energy fuel: Eventually, most Leu is broken down, providing about 6.0kcal/g. About 60% of ingested Leu is oxidized within a few hours ... Ketogenesis: A significant proportion (40% of an ingested dose) is converted into acetyl-CoA and thereby contributes to the synthesis of ketones, steroids, fatty acids, and other compounds"
Figure 8.57: Metabolism of L-leucine
- "Leucine metabolism". Technische Universität Braunschweig. http://www.brenda-enzymes.org/pathways/Maps/pathways/leucine_metabolism.svg.
- "Human Metabolome Database: Showing metabocard for Beta-Leucine (HMDB0003640)". http://www.hmdb.ca/metabolites/HMDB03640.
Original source: https://en.wikipedia.org/wiki/ Β-Leucine. Read more