Chemistry:Tiglyl-CoA
From HandWiki
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Names | |
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IUPAC name
3′-O-Phosphonoadenosine 5′-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-methylbut-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-oxobutyl dihydrogen diphosphate]
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Systematic IUPAC name
O1-{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)oxolan-2-yl]methyl} O3-[(3R)-3-hydroxy-2,2-dimethyl-4-({3-[(2-{[(2E)-methylbut-2-enoyl]sulfanyl}ethyl)amino]-3-oxopropyl}amino)-4-oxobutyl] dihydrogen diphosphate | |
Identifiers | |
3D model (JSmol)
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MeSH | tiglyl-coenzyme+A |
PubChem CID
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Properties | |
C26H42N7O17P3S | |
Molar mass | 849.63 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Infobox references | |
Tracking categories (test):
Tiglyl-CoA is an intermediate in the metabolism of isoleucine.[1][2] It is an inhibitor of N-acetylglutamate synthetase.[3]
References
- ↑ ROBINSON WG; BACHHAWAT BK; COON MJ (1956). "TIGLYL COENZYME A AND a-METHYLACETOACETYL COENZYME A, INTERMEDIATES IN THE ENZYMATIC DEGRADATION OF ISOLEUCINE". Journal of Biological Chemistry 218 (1): 391–400. doi:10.1016/S0021-9258(18)65902-2. PMID 13278346.
- ↑ "Showing metabocard for Tiglyl-CoA (HMDB02054)". The Metabolomics Innovation Centre (TMIC). http://www.hmdb.ca/metabolites/HMDB02054.
- ↑ Coude, F X; Sweetman, L; Nyhan, W L (1979). "Inhibition by propionyl-coenzyme A of N-acetylglutamate synthetase in rat liver mitochondria. A possible explanation for hyperammonemia in propionic and methylmalonic acidemia". Journal of Clinical Investigation 64 (6): 1544–1551. doi:10.1172/JCI109614. PMID 500823.
![]() | Original source: https://en.wikipedia.org/wiki/Tiglyl-CoA.
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