Biology:MYO1E
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.[1][2]
Myosin-Ie is a long tailed myosin. It contains an N-terminal motor domain, an IQ motif, a TH1 domain containing a plecstrin homology (PH) domain, a proline rich TH2 domain, and an SH3 domain. [3]
The MYO1E gene was included in several genetic signatures for cancer prognosis.[4]
References
- ↑ "Mapping of unconventional myosins in mouse and human". Genomics 36 (3): 431–439. September 1996. doi:10.1006/geno.1996.0488. PMID 8884266.
- ↑ "Entrez Gene: MYO1E myosin IE". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4643.
- ↑ "Leveraging the membrane - cytoskeleton interface with myosin-1". Trends in Cell Biology 20 (7): 418–426. July 2010. doi:10.1016/j.tcb.2010.04.004. PMID 20471271.
- ↑ "Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning". BioData Mining 15 (1). November 2022. doi:10.1186/s13040-022-00312-y. PMID 36329531.
Further reading
- "Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis". FEBS Letters 581 (4): 644–650. February 2007. doi:10.1016/j.febslet.2007.01.021. PMID 17257598. Bibcode: 2007FEBSL.581..644K.
- "The kinetic mechanism of Myo1e (human myosin-IC)". The Journal of Biological Chemistry 277 (24): 21514–21521. June 2002. doi:10.1074/jbc.M200713200. PMID 11940582.
- "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motility and the Cytoskeleton 41 (4): 308–324. 1999. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.
- "A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components". Biochemical and Biophysical Research Communications 240 (1): 46–50. November 1997. doi:10.1006/bbrc.1997.7608. PMID 9367879. Bibcode: 1997BBRC..240...46R.
- "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proceedings of the National Academy of Sciences of the United States of America 91 (14): 6549–6553. July 1994. doi:10.1073/pnas.91.14.6549. PMID 8022818. Bibcode: 1994PNAS...91.6549B.
- "Cloning and mRNA expression of human unconventional myosin-IC. A homologue of amoeboid myosins-I with a single IQ motif and an SH3 domain". Journal of Molecular Biology 243 (2): 356–363. October 1994. doi:10.1006/jmbi.1994.1662. PMID 7932763.
External links
- Overview of all the structural information available in the PDB for UniProt: E9Q634 (Mouse Unconventional myosin-Ie) at the PDBe-KB.
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