Chemistry:Dazucorilant
From HandWiki
Dazucorilant (CORT-113176) is an example of a selective glucocorticoid receptor modulator that is in clinical development.[1] It is expected to have uses in the treatment of neurodegenerative diseases, Alzheimer's disease and Huntington's chorea, for example.[2][3][4]
See also
- CORT-108297
- Miricorilant
- Nivazol – has the same pyrazole ring moiety
- Relacorilant
References
- ↑ "1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile". Bioorganic & Medicinal Chemistry Letters 25 (24): 5720–5725. December 2015. doi:10.1016/j.bmcl.2015.10.097. PMID 26546213.
- ↑ "The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord". Neuroscience 384: 384–396. August 2018. doi:10.1016/j.neuroscience.2018.05.042. PMID 29890290.
- ↑ "Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration". Brain Research 1727. January 2020. doi:10.1016/j.brainres.2019.146551. PMID 31726042.
- ↑ "Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice". Experimental Neurology 374. April 2024. doi:10.1016/j.expneurol.2024.114675. PMID 38216109.
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