Chemistry:Dazucorilant
From HandWiki
Dazucorilant (CORT-113176) is an example of a selective glucocorticoid receptor modulator that is in clinical development.[1] It is expected to have uses in the treatment of neurodegenerative diseases, Alzheimer's disease and Huntington's chorea, for example.[2][3][4]
See also
- CORT-108297
- Miricorilant
- Nivazol – has the same pyrazole ring moiety
- Relacorilant
References
- ↑ Hunt, H. J.; Belanoff, J. K.; Golding, E.; Gourdet, B.; Phillips, T.; Swift, D.; Thomas, J.; Unitt, J. F. et al. (December 2015). "1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile". Bioorganic & Medicinal Chemistry Letters 25 (24): 5720–5725. doi:10.1016/j.bmcl.2015.10.097. PMID 26546213.
- ↑ Meyer, M.; Lara, A.; Hunt, H.; Belanoff, J.; Kloet, E. R. de; Gonzalez Deniselle, M. C.; De Nicola, A. F. (August 2018). "The Selective Glucocorticoid Receptor Modulator Cort 113176 Reduces Neurodegeneration and Neuroinflammation in Wobbler Mice Spinal Cord". Neuroscience 384: 384–396. doi:10.1016/j.neuroscience.2018.05.042. PMID 29890290.
- ↑ Meyer, M.; Kruse, M. S.; Garay, L.; Lima, A.; Roig, P.; Hunt, H.; Belanoff, J.; Kloet, E. R. de et al. (January 2020). "Long-term effects of the glucocorticoid receptor modulator CORT113176 in murine motoneuron degeneration". Brain Research 1727. doi:10.1016/j.brainres.2019.146551. PMID 31726042.
- ↑ Gentenaar, M.; Meulmeester, F. L.; Burg, X. R. van der; Hoekstra, A. T.; Hunt, H.; Kroon, J.; Roon-Mom, W. M. C. van; Meijer, O. C. (April 2024). "Glucocorticoid receptor antagonist CORT113176 attenuates motor and neuropathological symptoms of Huntington's disease in R6/2 mice". Experimental Neurology 374. doi:10.1016/j.expneurol.2024.114675. PMID 38216109.
 |  |
