Chemistry:Dexamethasone-BSA

From HandWiki

Dexamethasone-BSA, also known as dexamethasone-bovine serum albumin conjugate, is a conjugate of the corticosteroid dexamethasone and the serum albumin bovine serum albumin (BSA).[1] It is a membrane-limited glucocorticoid that is unable to diffuse into cells and can dissociate rapid membrane-mediated glucocorticoid receptor effects from intracellular or genomic effects.[1] The drug is used in scientific research to study the actions of membrane glucocorticoid receptors.[1][2][3][4]

References

  1. ↑ 1.0 1.1 1.2 "Purity and stability of the membrane-limited glucocorticoid receptor agonist dexamethasone-BSA". Steroids 142: 2–5. February 2019. doi:10.1016/j.steroids.2017.09.004. PMID 28939328. 
  2. ↑ "Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling". Endocrinology 151 (10): 4811–4819. October 2010. doi:10.1210/en.2010-0285. PMID 20702575. 
  3. ↑ "Origin and functional activity of the membrane-bound glucocorticoid receptor". Arthritis and Rheumatism 63 (12): 3779–3788. December 2011. doi:10.1002/art.30637. PMID 21898343. 
  4. ↑ "Spinal microglial membrane glucocorticoid receptors regulate anti-hypersensitivity by stimulating dynorphin A expression". European Journal of Pharmacology 1010. January 2026. doi:10.1016/j.ejphar.2025.178362. PMID 41276104. 



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