Chemistry:Fosgonimeton
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Fosgonimeton is an investigational new drug that is being evaluated to treat neurodegenerative diseases such as Alzheimer's and Parkinson's disease.[1] It is a pro-drug of the active metabolite dihexa. Dihexa in turn binds to the hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met.[2][3]
References
- ↑ "Fosgonimeton - Athira Pharma". AdisInsight. Springer Nature Switzerland AG. https://adisinsight.springer.com/drugs/800050463.
- ↑ "Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia". Neurotherapeutics 20 (2): 431–451. March 2023. doi:10.1007/s13311-022-01325-5. PMID 36538176.
- ↑ "Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease". Neurotherapeutics 21 (4). July 2024. doi:10.1016/j.neurot.2024.e00350. PMID 38599894.
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