Chemistry:4-Hydroxyphenylpyruvic acid
From HandWiki
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| Names | |
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| Preferred IUPAC name
3-(4-Hydroxyphenyl)-2-oxopropanoic acid | |
| Other names
4-Hydroxyphenylpyruvate
p-Hydroxyphenylpyruvic acid p-Hydroxyphenylpyruvate | |
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| Properties | |
| C9H8O4 | |
| Molar mass | 180.157 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
4-Hydroxyphenylpyruvic acid (4-HPPA) is an intermediate in the metabolism of the amino acid phenylalanine. The aromatic side chain of phenylalanine is hydroxylated by the enzyme phenylalanine hydroxylase to form tyrosine. The conversion from tyrosine to 4-HPPA is in turn catalyzed by tyrosine aminotransferase.[1] Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment.[2]
It is an intermediary compound in the biosynthesis of scytonemin.
See also
References
- ↑ Brand, Larry; Harper, Alfred (1974). "Effect of glucagon on phenylalanine metabolism and phenylalanine-degrading enzymes in the rat". Biochemical Journal 142 (2): 231–45. doi:10.1042/bj1420231. PMID 4155291.
- ↑ Denoya, Claudio; Skinner, Deborah; Morgenstern, Margaret (September 1994). "A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli". Journal of Bacteriology 1 (17): 5312–5319. doi:10.1128/jb.176.17.5312-5319.1994. PMID 8071207.
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