Chemistry:PF-3845
From HandWiki
Short description: Chemical compound
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| Formula | C24H23F3N4O2 |
| Molar mass | 456.469 g·mol−1 |
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PF-3845 is a selective inhibitor of fatty acid amide hydrolase.[1] It results in increased levels of anandamide and results in cannabinoid receptor-based effects. It has anti-inflammatory action in mice colitis models. Antidiarrheal and antinociceptive effects were also seen in mouse models of pain.[2]
A 2017 study published in the Journal of Psychiatry and Neuroscience found that PF-3845 exerts rapid and long-lasting anti-anxiety effects in mice exposed acutely to stress or chronically to the stress hormone corticosterone.[3]
References
- ↑ "Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain". Chemistry & Biology 16 (4): 411–20. April 2009. doi:10.1016/j.chembiol.2009.02.013. PMID 19389627.
- ↑ "Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides". Neurogastroenterology and Motility 26 (4): 470–81. April 2014. doi:10.1111/nmo.12272. PMID 24460851.
- ↑ "Fatty acid amide hydrolase inhibitors produce rapid anti-anxiety responses through amygdala long-term depression in male rodents". Journal of Psychiatry & Neuroscience 42 (4): 230–241. June 2017. doi:10.1503/jpn.160116. PMID 28234213.
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