Chemistry:VDM-11
From HandWiki
VDM-11 is a potent cannabinoid reuptake inhibitor. This is achieved by inhibiting the anandamide membrane transporter (AMT) which is responsible for reuptake of anandamide.[1]
It is light-sensitive and must be stored within an inert gas such as argon, in a dark place and at an ideal temperature of -20 °C or lower.[2] This tan-colored substance is rarely found outside of research laboratories.
VDM-11 is a weak CB1 agonist with a binding affinity of Ki > 5–10 μM.[3][4]
See also
- AM-404
References
- ↑ "VDM-11 | CAS 313998-81-1 | SCBT - Santa Cruz Biotechnology". https://www.scbt.com/p/vdm-11-313998-81-1.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs nameddatasheet - ↑ De Petrocellis, Luciano; Bisogno, Tiziana; Davis, John B.; Pertwee, Roger G.; Di Marzo, Vincenzo (2000). "Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity". FEBS Letters 483 (1): 52–56. doi:10.1016/S0014-5793(00)02082-2. PMID 11033355. Bibcode: 2000FEBSL.483...52D. https://febs.onlinelibrary.wiley.com/doi/10.1016/S0014-5793%2800%2902082-2.
- ↑ Schindler, Charles W.; Scherma, Maria; Redhi, Godfrey H.; Vadivel, Subramanian K.; Makriyannis, Alexandros; Goldberg, Steven R.; Justinova, Zuzana (2016). "Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys". Psychopharmacology 233 (10): 1867–1877. doi:10.1007/s00213-016-4211-3. PMID 26803499.
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