Biology:ABHD6
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alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene.
Function
ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.[1]
ABHD6 has been linked to regulation of the endocannabinoid system as it controls the accumulation of 2-arachidonoylglycerol (2-AG) at the cannabinoid receptors.[2]
ABHD6 accounts for about 4% of 2-AG brain hydrolysis.[3] Together, monoacylglycerol lipase (MAGL), ABHD12, and ABHD6 control about 99% of 2-AG signalling in the brain,[3][4] and each enzyme exhibits a distinct subcellular distribution, suggesting that they regulate distinct pools of 2-AG in the nervous system.[5]
See also
References
- ↑ "An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines". Molecular Biology Reports 36 (4): 691–6. April 2009. doi:10.1007/s11033-008-9230-7. PMID 18360779.
- ↑ "The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors". Nature Neuroscience 13 (8): 951–7. August 2010. doi:10.1038/nn.2601. PMID 20657592.
- ↑ 3.0 3.1 Cannabinoid Receptors—Advances in Research and Application: 2012 Edition: ScholarlyBrief. ScholarlyEditions. 26 December 2012. pp. 68–. ISBN 978-1-4816-0672-1. https://books.google.com/books?id=QZqtIuUdJnQC&pg=PA68.
- ↑ "The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors". Acta Physiologica 204 (2): 267–76. February 2012. doi:10.1111/j.1748-1716.2011.02280.x. PMID 21418147.
- ↑ "A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol". Chemistry & Biology 14 (12): 1347–56. December 2007. doi:10.1016/j.chembiol.2007.11.006. PMID 18096503.
External links
- Human ABHD6 genome location and ABHD6 gene details page in the UCSC Genome Browser.
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