Chemistry:2-Oleoylglycerol
From HandWiki
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| Names | |
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| IUPAC name
2-O-[(9Z)-Octadec-9-enoyl]glycerol
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| Systematic IUPAC name
1,3-Dihydroxypropan-2-yl (9Z)-octadec-9-enoate | |
| Other names
2-Monoolein
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C21H40O4 | |
| Molar mass | 356.547 g·mol−1 |
| Density | 0.958 g/cm3 |
| Hazards | |
| Flash point | > 113.0 °C (235.4 °F; 386.1 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
2-Oleoylglycerol (2OG) is a monoacylglycerol that is found in biologic tissues. Its synthesis is derived from diacylglycerol precursors. It is metabolized to oleic acid and glycerol primarily by the enzyme monoacylglycerol lipase (MAGL).[1] In 2011, 2OG was found to be an endogenous ligand to GPR119.[2] 2OG has been shown to increase glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels following administration to the small intestine.[2]
See also
References
- ↑ Dinh, T. P.; Carpenter, D.; Leslie, F. M.; Freund, T. F.; Katona, I.; Sensi, S. L.; Kathuria, S.; Piomelli, D. (2002). "Brain monoglyceride lipase participating in endocannabinoid inactivation". Proceedings of the National Academy of Sciences 99 (16): 10819–10824. doi:10.1073/pnas.152334899. PMID 12136125. Bibcode: 2002PNAS...9910819D.
- ↑ 2.0 2.1 Hansen, K. B.; Rosenkilde, M. M.; Knop, F. K.; Wellner, N.; Diep, T. A.; Rehfeld, J. F.; Andersen, U. B.; Holst, J. J. et al. (2011). "2-Oleoyl Glycerol is a GPR119 Agonist and Signals GLP-1 Release in Humans". Journal of Clinical Endocrinology & Metabolism 96 (9): E1409–E1417. doi:10.1210/jc.2011-0647. PMID 21778222.
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