Chemistry:O-1918

From HandWiki

O-1918 is a synthetic compound related to cannabidiol, which is an antagonist at two former orphan receptors GPR18 and GPR55, that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB1, non-CB2 mediated effects that have become evident in the course of cannabinoid research.[1][2][3][4][5]

Subsequent research by using electrophysiological approach has shown that O-1918 is a potent BKCa channel inhibitor.[6][7][8]

See also

References

  1. ↑ "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular Pharmacology 63 (3): 699–705. March 2003. doi:10.1124/mol.63.3.699. PMID 12606780. 
  2. ↑ "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats". British Journal of Pharmacology 160 (3): 574–84. June 2010. doi:10.1111/j.1476-5381.2009.00579.x. PMID 20105178. 
  3. ↑ "The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55". Neuroscience Letters 500 (1): 72–6. August 2011. doi:10.1016/j.neulet.2011.06.004. PMID 21683763. 
  4. ↑ "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure". Journal of Ocular Pharmacology and Therapeutics 27 (5): 427–35. October 2011. doi:10.1089/jop.2011.0041. PMID 21770780. 
  5. ↑ "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology 169 (4): 834–43. June 2013. doi:10.1111/bph.12136. PMID 23461720. 
  6. ↑ "The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels". The Journal of Pharmacology and Experimental Therapeutics 328 (1): 351–361. January 2009. doi:10.1124/jpet.108.144717. PMID 18923087. 
  7. ↑ "The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells". Vascular Pharmacology 102: 44–55. March 2018. doi:10.1016/j.vph.2018.01.004. PMID 29355732. 
  8. ↑ "Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor". European Journal of Pharmacology 805: 14–24. June 2017. doi:10.1016/j.ejphar.2017.03.038. PMID 28327344. 



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