Chemistry:O-1918
From HandWiki
Short description: Chemical compound
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| Formula | C19H26O2 |
| Molar mass | 286.415 g·mol−1 |
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O-1918 is a synthetic compound related to cannabidiol, which is an antagonist at two former orphan receptors GPR18 and GPR55, that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB1, non-CB2 mediated effects that have become evident in the course of cannabinoid research.[1][2][3][4][5]
See also
- Abnormal cannabidiol
- Cannabidiol dimethyl ether
- CID-16020046
- CID-85469571
- O-1602
- O-1821
- Tetrahydrocannabiorcol
References
- ↑ "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular Pharmacology 63 (3): 699–705. March 2003. doi:10.1124/mol.63.3.699. PMID 12606780.
- ↑ "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats". British Journal of Pharmacology 160 (3): 574–84. June 2010. doi:10.1111/j.1476-5381.2009.00579.x. PMID 20105178.
- ↑ "The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55". Neuroscience Letters 500 (1): 72–6. August 2011. doi:10.1016/j.neulet.2011.06.004. PMID 21683763.
- ↑ "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure". Journal of Ocular Pharmacology and Therapeutics 27 (5): 427–35. October 2011. doi:10.1089/jop.2011.0041. PMID 21770780.
- ↑ "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology 169 (4): 834–43. June 2013. doi:10.1111/bph.12136. PMID 23461720.
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