Biology:SLC10A1
 Generic protein structure example |
Sodium/bile acid cotransporter also known as the Na+-taurocholate cotransporting polypeptide (NTCP) or liver bile acid transporter (LBAT) is a protein that in humans is encoded by the SLC10A1 (solute carrier family 10 member 1) gene.[1][2]
Structure
Sodium/bile acid cotransporters are integral membrane glycoproteins. Human NTCP contains 349 amino acids and has a mass of 56 kDa.[3]
Function
Bile acids participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids. One of these absorbs bile acids from the intestinal lumen, the bile duct, and the kidney with an apical localization (ileal sodium/bile acid cotransporter). The other is this protein and is expressed in the basolateral membranes of hepatocytes (NTCP).[3]
As a cotransporter, NTCP binds two sodium ions and one (conjugated) bile salt molecule, thereby providing an hepatic influx of bile salts. Other transported molecules include steroid hormones, thyroid hormones and various xenobiotics:[3]
Hepatitis virus entry
NTCP is a cell surface receptor necessary for the entry of hepatitis B and hepatitis D virus.[4] This entry mechanism is inhibited by myrcludex B,[5] cyclosporin A, progesterone, propranolol, bosentan, ezetimibe, as well as NTCP substrates like taurocholate, tauroursodeoxycholate and bromosulfophthalein.[3]
See also
References
- ↑ "Entrez Gene: SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6554.
- ↑ "Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter". The Journal of Clinical Investigation 93 (3): 1326–31. March 1994. doi:10.1172/JCI117091. PMID 8132774.
- ↑ 3.0 3.1 3.2 3.3 "NTCP and beyond: opening the door to unveil hepatitis B virus entry". International Journal of Molecular Sciences 15 (2): 2892–905. February 2014. doi:10.3390/ijms15022892. PMID 24557582.
- ↑ "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife 1: e00049. November 2012. doi:10.7554/eLife.00049. PMID 23150796.
- ↑ H. Spreitzer (14 September 2015). "Neue Wirkstoffe – Myrcludex B" (in German). Österreichische Apothekerzeitung (19/2015): 12.
Further reading
- "Bile salt transporters: molecular characterization, function, and regulation". Physiological Reviews 83 (2): 633–71. April 2003. doi:10.1152/physrev.00027.2002. PMID 12663868.
- "Structural and functional characterization of liver cell-specific activity of the human sodium/taurocholate cotransporter". Genomics 69 (2): 203–13. October 2000. doi:10.1006/geno.2000.6329. PMID 11031103.
- "Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice". The Biochemical Journal 361 (Pt 3): 673–9. February 2002. doi:10.1042/0264-6021:3610673. PMID 11802798.
- "Organization of the membrane domain of the human liver sodium/bile acid cotransporter". Biochemistry 41 (23): 7253–66. June 2002. doi:10.1021/bi012152s. PMID 12044156.
- "Ethnicity-dependent polymorphism in Na+-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition". The Journal of Biological Chemistry 279 (8): 7213–22. February 2004. doi:10.1074/jbc.M305782200. PMID 14660639.
- "Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene". American Journal of Physiology. Gastrointestinal and Liver Physiology 286 (5): G752–61. May 2004. doi:10.1152/ajpgi.00456.2003. PMID 14701722.
- "Cholesterol modulates human intestinal sodium-dependent bile acid transporter". American Journal of Physiology. Gastrointestinal and Liver Physiology 288 (5): G978–85. May 2005. doi:10.1152/ajpgi.00379.2004. PMID 15604201.
- "Developmental expression of canalicular transporter genes in human liver". Journal of Hepatology 43 (3): 472–7. September 2005. doi:10.1016/j.jhep.2005.02.030. PMID 15922475.
- "Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp". The Journal of Biological Chemistry 280 (39): 33687–92. September 2005. doi:10.1074/jbc.M502151200. PMID 16027164.
- "The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism". Molecular Endocrinology 20 (1): 65–79. January 2006. doi:10.1210/me.2005-0159. PMID 16123152.
- "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells". Fundamental & Clinical Pharmacology 21 (4): 445–50. August 2007. doi:10.1111/j.1472-8206.2007.00517.x. PMID 17635184.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |
