Biology:SLC30A3
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Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.[1]
The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles.[2] In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala.[3] Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.[4] Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.[5]
See also
References
- ↑ "Entrez Gene: Solute carrier family 30 (zinc transporter), member 3". https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=7781.
- ↑ "Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1716–21. February 1999. doi:10.1073/pnas.96.4.1716. PMID 9990090.
- ↑ "Modulation of neuronal signal transduction and memory formation by synaptic zinc". Frontiers in Behavioral Neuroscience 5: 68. 2011. doi:10.3389/fnbeh.2011.00068. PMID 22084630.
- ↑ "Unraveling the role of zinc in memory". Proceedings of the National Academy of Sciences of the United States of America 108 (8): 3103–4. February 2011. doi:10.1073/pnas.1100323108. PMID 21321213.
- ↑ "Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells". PLoS One 7 (3): e33211. 2012. doi:10.1371/journal.pone.0033211. PMID 22427991.
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