Biology:SLCO1B1

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.[1][2] Pharmacogenomic research indicates that genetic variations in this gene are associated with response to simvastatin.[3] Clinical guidelines exist that can guide dosing of simvastatin based on SLCO1B1 gene variant using genotyping or whole exome sequencing.[4]

See also

References

  1. ↑ "Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1". J Biol Chem 274 (24): 17159–63. Jul 1999. doi:10.1074/jbc.274.24.17159. PMID 10358072. 
  2. ↑ "Entrez Gene: SLCO1B1 solute carrier organic anion transporter family, member 1B1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10599. 
  3. ↑ "SLCO1B1 Genetic Variant Associated with Statin-Induced Myopathy: A Proof-of-Concept Study Using the Clinical Practice Research Datalink". Clinical Pharmacology & Therapeutics 94 (6): 695–701. 2013. doi:10.1038/clpt.2013.161. PMID 23942138. 
  4. ↑ "Providing pharmacogenomics clinical decision support using whole genome sequencing data as input". AMIA Summits on Translational Science proceedings AMIA Summit on Translational Science 2013: 81. 2013. PMID 24303303. 

Further reading

  • "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. 2000. doi:10.1074/jbc.274.52.37161. PMID 10601278. 
  • "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. 2000. PMID 10644574. 
  • "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. 2000. doi:10.4049/jimmunol.164.6.3169. PMID 10706707. 
  • "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. 2000. doi:10.1074/jbc.M001448200. PMID 10779507. 
  • "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. 2000. doi:10.1006/bbrc.2000.2922. PMID 10873595. 
  • "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. 2001. doi:10.1074/jbc.M004968200. PMID 11134001. 
  • "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. 2001. doi:10.1074/jbc.M103792200. PMID 11477075. 
  • "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. 2001. doi:10.1074/jbc.M103988200. PMID 11483603. 
  • "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. 2002. doi:10.1124/jpet.302.2.804. PMID 12130747. 
  • "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. 2003. doi:10.1074/jbc.M207735200. PMID 12196548. 
  • "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. 2003. doi:10.1124/jpet.102.043026. PMID 12490595. 
  • "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. 2003. doi:10.1074/jbc.M301100200. PMID 12670950. 
  • "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. 2003. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. 
  • "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics 14 (7): 429–40. 2005. doi:10.1097/01.fpc.0000114750.08559.32. PMID 15226675. 
  • "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. 2005. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464. 
  • "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. 2005. doi:10.1016/j.cbi.2004.08.008. PMID 15535988. 
  • "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics 15 (1): 43–50. 2005. doi:10.1097/01213011-200501000-00007. PMID 15864125. 
  • "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. 2006. doi:10.1016/j.clpt.2005.11.003. PMID 16513443. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.





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