Biology:SLC22A1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Solute carrier family 22 member 1 is a protein that in humans is encoded by the gene SLC22A1.[1][2]
Function
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.[2]
It is also required for the uptake of metformin by cells.[3][4]
See also
References
- ↑ "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenetics and Cell Genetics 79 (3–4): 198–200. Jun 1998. doi:10.1159/000134720. PMID 9605850.
- ↑ 2.0 2.1 "Entrez Gene: SLC22A1 solute carrier family 22 (organic cation transporter), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6580.
- ↑ Pryor, R; Cabreiro, F; Haberland, G (16 October 2015). "Repurposing metformin: an old drug with new tricks in its binding pockets". Biochemical Journal 471 (3): 307–322. doi:10.1042/BJ20150497. PMID 26475449.
- ↑ Rosilio, C; Ben-Sahra, I; Bost, F; Peyron, JF (1 May 2014). "Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia.". Cancer Letters 346 (2): 188–96. doi:10.1016/j.canlet.2014.01.006. PMID 24462823.
Further reading
- "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". Journal of Virology 66 (1): 139–49. January 1992. doi:10.1128/JVI.66.1.139-149.1992. PMID 1727476.
- "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology 67 (10): 6224–33. October 1993. doi:10.1128/JVI.67.10.6224-6233.1993. PMID 7690421.
- "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS 10 (12): 1323–9. October 1996. doi:10.1097/00002030-199610000-00003. PMID 8902060.
- "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". The Biochemical Journal 322 (Pt 1): 155–8. February 1997. doi:10.1042/bj3220155. PMID 9078256.
- "Cloning and functional expression of a human liver organic cation transporter". Molecular Pharmacology 51 (6): 913–21. June 1997. doi:10.1124/mol.51.6.913. PMID 9187257.
- "Cloning and characterization of two human polyspecific organic cation transporters". DNA and Cell Biology 16 (7): 871–81. July 1997. doi:10.1089/dna.1997.16.871. PMID 9260930.
- "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics 55 (2): 209–18. January 1999. doi:10.1006/geno.1998.5639. PMID 9933568.
- "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes & Development 13 (20): 2650–7. October 1999. doi:10.1101/gad.13.20.2650. PMID 10541551.
- "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell 103 (6): 853–64. December 2000. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971.
- "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Annals of Human Genetics 63 (Pt 6): 473–82. November 1999. doi:10.1046/j.1469-1809.2000.6430267.x. PMID 11388889.
- "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". The Journal of Biological Chemistry 276 (36): 33741–6. September 2001. doi:10.1074/jbc.M104617200. PMID 11447227.
- "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1–2): 58–64. September 2001. doi:10.1006/geno.2001.6614. PMID 11543633.
- "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America 98 (26): 15089–94. December 2001. doi:10.1073/pnas.241522398. PMID 11752456. Bibcode: 2001PNAS...9815089X.
- "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics 12 (8): 589–90. November 2002. doi:10.1097/00008571-200211000-00001. PMID 12439217.
- "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics 12 (8): 591–5. November 2002. doi:10.1097/00008571-200211000-00002. PMID 12439218.
- "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". The Journal of Biological Chemistry 278 (25): 23141–50. June 2003. doi:10.1074/jbc.M212952200. PMID 12672812.
- "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proceedings of the National Academy of Sciences of the United States of America 100 (10): 5902–7. May 2003. doi:10.1073/pnas.0730858100. PMID 12719534. Bibcode: 2003PNAS..100.5902S.
- "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochemical and Biophysical Research Communications 313 (3): 789–93. January 2004. doi:10.1016/j.bbrc.2003.11.175. PMID 14697261.
- "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta 25 (6): 518–29. July 2004. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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