Biology:SLC22A4

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.[1][2]

Function

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.[3] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").[1]

Interactions

SLC22A4 has been shown to interact with PDZK1.[4]

See also

References

  1. ↑ 1.0 1.1 Gründemann, Dirk; Hartmann, Lea; Flögel, Svenja (May 2022). "The ergothioneine transporter (ETT): substrates and locations, an inventory". FEBS Letters 596 (10): 1252–1269. doi:10.1002/1873-3468.14269. PMID 34958679. 
  2. ↑ "Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583. 
  3. ↑ "Discovery of the ergothioneine transporter". Proceedings of the National Academy of Sciences of the United States of America 102 (14): 5256–61. Apr 2005. doi:10.1073/pnas.0408624102. PMID 15795384. Bibcode: 2005PNAS..102.5256G. 
  4. ↑ "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International 64 (5): 1733–45. Nov 2003. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806. 

Further reading

  • "Characterization of organic cation/carnitine transporter family in human sperm". Biochemical and Biophysical Research Communications 306 (1): 121–8. Jun 2003. doi:10.1016/S0006-291X(03)00930-6. PMID 12788076. 
  • "SLC22A4 and RUNX1: identification of RA susceptible genes". Journal of Molecular Medicine 82 (9): 558–64. Sep 2004. doi:10.1007/s00109-004-0547-y. PMID 15184985. 
  • "OCTNs: will the real IBD5 gene please stand up?". World Journal of Gastroenterology 12 (23): 3678–81. Jun 2006. doi:10.3748/wjg.v12.i23.3678. PMID 16773684. 
  • "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1". FEBS Letters 419 (1): 107–11. Dec 1997. doi:10.1016/S0014-5793(97)01441-5. PMID 9426230. 
  • "Membrane localization of the electrogenic cation transporter rOCT1 in rat liver". Biochemical and Biophysical Research Communications 248 (3): 673–8. Jul 1998. doi:10.1006/bbrc.1998.9034. PMID 9703985. 
  • "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs". The Journal of Pharmacology and Experimental Therapeutics 287 (2): 800–5. Nov 1998. PMID 9808712. 
  • "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations". The Journal of Pharmacology and Experimental Therapeutics 289 (2): 768–73. May 1999. PMID 10215651. 
  • "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". The Journal of Pharmacology and Experimental Therapeutics 303 (2): 487–96. Nov 2002. doi:10.1124/jpet.102.038315. PMID 12388627. 
  • "Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population". Journal of Human Genetics 47 (11): 576–84. 2003. doi:10.1007/s100380200088. PMID 12436193. 
  • "Organic anion and cation transporters occur in pairs of similar and similarly expressed genes". Biochemical and Biophysical Research Communications 300 (2): 333–42. Jan 2003. doi:10.1016/S0006-291X(02)02853-X. PMID 12504088. 
  • "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International 64 (5): 1733–45. Nov 2003. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806. 
  • "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis". Nature Genetics 35 (4): 341–8. Dec 2003. doi:10.1038/ng1267. PMID 14608356. 
  • "Functional variants of OCTN cation transporter genes are associated with Crohn disease". Nature Genetics 36 (5): 471–5. May 2004. doi:10.1038/ng1339. PMID 15107849. 
  • "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population". Journal of Pharmaceutical Sciences 93 (12): 2920–6. Dec 2004. doi:10.1002/jps.20190. PMID 15459889. 
  • "A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease". Gastroenterology 128 (2): 260–9. Feb 2005. doi:10.1053/j.gastro.2004.11.056. PMID 15685536. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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