Biology:SLC6A15
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 Generic protein structure example |
Solute carrier family 6 member 15 (SLC6A15) also known as the sodium-dependent neutral amino acid transporter B(0)AT2 (B0AT2)' is a protein that in humans is encoded by the SLC6A15 gene.[1]
Function
SLC6A15 shows structural characteristics of an Na+ and Cl−-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[2]
Clinical relevance
Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[3]
References
- ↑ "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55117.
- ↑ "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics 70 (2): 241–52. Dec 2000. doi:10.1006/geno.2000.6387. PMID 11112352.
- ↑ "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron 70 (2): 252–65. Apr 2011. doi:10.1016/j.neuron.2011.04.005. PMID 21521612.
Further reading
- "The orphan transporter v7-3 (slc6a15) is a Na+-dependent neutral amino acid transporter (B0AT2)". The Biochemical Journal 393 (Pt 1): 421–30. Jan 2006. doi:10.1042/BJ20051273. PMID 16185194.
- "Synaptic Vesicle Protein NTT4/XT1 (SLC6A17) Catalyzes Na+-coupled Neutral Amino Acid Transport". The Journal of Biological Chemistry 284 (13): 8439–48. Mar 2009. doi:10.1074/jbc.M806407200. PMID 19147495.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Amino acid transport across mammalian intestinal and renal epithelia". Physiological Reviews 88 (1): 249–86. Jan 2008. doi:10.1152/physrev.00018.2006. PMID 18195088.
- "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain". Biochemical and Biophysical Research Communications 337 (3): 892–900. Nov 2005. doi:10.1016/j.bbrc.2005.09.128. PMID 16226721.
- "Neurotransmitter transporters in the central nervous system". Pharmacological Reviews 51 (3): 439–64. Sep 1999. PMID 10471414.
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