Biology:SLC17A3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Solute carrier family 17 (organic anion transporter), member 3 is a protein that in humans is encoded by the SLC17A3 gene.

Function

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum.

See also

• Glycogen storage disease type I

Further reading

• "Common variants in SLC17A3 gene affect intra-personal variation in serum uric acid levels in longitudinal time series". Croat. Med. J. 51 (1): 32–9. 2010. doi:10.3325/cmj.2010.51.32. PMID 20162743. 
• "Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study". Lancet 372 (9654): 1953–61. 2008. doi:10.1016/S0140-6736(08)61343-4. PMID 18834626. 
• "A 1.1-Mb transcript map of the hereditary hemochromatosis locus". Genome Res. 7 (5): 441–56. 1997. doi:10.1101/gr.7.5.441. PMID 9149941. 
• "Human sodium phosphate transporter 4 (hNPT4/SLC17A3) as a common renal secretory pathway for drugs and urate". J. Biol. Chem. 285 (45): 35123–32. 2010. doi:10.1074/jbc.M110.121301. PMID 20810651. 
• "Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease". PLOS ONE 4 (11): e7729. 2009. doi:10.1371/journal.pone.0007729. PMID 19890391. Bibcode: 2009PLoSO...4.7729S. 
• "Functional analysis of human sodium-phosphate transporter 4 (NPT4/SLC17A3) polymorphisms". J. Pharmacol. Sci. 115 (2): 249–53. 2011. doi:10.1254/jphs.10228sc. PMID 21282933. https://www.jstage.jst.go.jp/article/jphs/115/2/115_10228SC/_pdf. 
• "NPT4, a new microsomal phosphate transporter: mutation analysis in glycogen storage disease type Ic". J. Inherit. Metab. Dis. 27 (6): 725–33. 2004. doi:10.1023/B:BOLI.0000045755.89308.2f. PMID 15505377. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.