Biology:SLC22A18
 Generic protein structure example |
Solute carrier family 22 member 18 is a protein that in humans is encoded by the SLC22A18 gene.[1][2][3]
Function
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[3]
See also
References
- ↑ "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Human Molecular Genetics 7 (4): 597–608. April 1998. doi:10.1093/hmg/7.4.597. PMID 9499412.
- ↑ "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proceedings of the National Academy of Sciences of the United States of America 95 (7): 3873–8. March 1998. doi:10.1073/pnas.95.7.3873. PMID 9520460. Bibcode: 1998PNAS...95.3873S.
- ↑ 3.0 3.1 "Entrez Gene: SLC22A18 solute carrier family 22 (organic cation transporter), member 18". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5002.
Further reading
- "[Mechanisms of drug resistance and reversal of the resistance]". Human Cell 14 (4): 257–60. December 2001. PMID 11925925.
- "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain". Genomics 49 (1): 38–51. April 1998. doi:10.1006/geno.1998.5221. PMID 9570947.
- "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules". FEBS Letters 433 (3): 245–50. August 1998. doi:10.1016/S0014-5793(98)00907-7. PMID 9744804.
- "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5". Cancer Research 58 (18): 4155–9. September 1998. PMID 9751628.
- "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice". DNA Research 5 (4): 235–40. August 1998. doi:10.1093/dnares/5.4.235. PMID 9802569.
- "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain". Genome Research 10 (11): 1697–710. November 2000. doi:10.1101/gr.161800. PMID 11076855.
- "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene 25 (9): 1330–9. March 2006. doi:10.1038/sj.onc.1209167. PMID 16314844.
- "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer". Genomics 88 (1): 12–7. July 2006. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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