Biology:SLC11A1
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Natural resistance-associated macrophage protein 1 is a protein that in humans is encoded by the SLC11A1 gene.[1][2][3]
Function
This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn's disease.[4] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]
See also
References
- ↑ "Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression". The Journal of Experimental Medicine 180 (5): 1741–52. November 1994. doi:10.1084/jem.180.5.1741. PMID 7964458.
- ↑ "Isolation and characterization of human Nramp cDNA". Biochemical and Biophysical Research Communications 204 (3): 1074–80. November 1994. doi:10.1006/bbrc.1994.2572. PMID 7980580.
- ↑ 3.0 3.1 "Entrez Gene: SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6556.
- ↑ "[Detection of Trichomonas in the bronchi, sputum and oral cavity in various lung diseases]". Terapevticheskii Arkhiv 52 (3): 123–5. 1980. PMID 7385031.
Further reading
- "Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story". Immunology Letters 85 (2): 197–203. January 2003. doi:10.1016/S0165-2478(02)00231-6. PMID 12527228.
- "The human solute carrier family 11 member 1 protein (SLC11A1): linking infections, autoimmunity and cancer?". FEMS Immunology and Medical Microbiology 49 (3): 324–9. April 2007. doi:10.1111/j.1574-695X.2007.00231.x. PMID 17378896.
- "Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene". American Journal of Human Genetics 56 (4): 845–53. April 1995. PMID 7717395.
- "Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg". Cell 73 (3): 469–85. May 1993. doi:10.1016/0092-8674(93)90135-D. PMID 8490962.
- "Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism". Molecular Medicine 1 (2): 194–205. January 1995. PMID 8529098.
- "Identification of natural resistance-associated macrophage protein in peripheral blood lymphocytes". Immunology Letters 47 (1-2): 93–6. 1996. doi:10.1016/0165-2478(95)00070-L. PMID 8537108.
- "Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome". The Journal of Experimental Medicine 185 (4): 717–30. February 1997. doi:10.1084/jem.185.4.717. PMID 9034150.
- "Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages". The Biochemical Journal. 325 325 ( Pt 3): 779–86. August 1997. PMID 9271100.
- "The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes". The Journal of Experimental Medicine 189 (5): 831–41. March 1999. doi:10.1084/jem.189.5.831. PMID 10049947.
- "Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility". Journal of Medical Genetics 36 (4): 295–9. April 1999. doi:10.1136/jmg.36.4.295. PMID 10227396.
- "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome 11 (9): 755–62. September 2000. doi:10.1007/s003350010151. PMID 10967134.
- "Expression and subcellular localization of NRAMP1 in human neutrophil granules". Blood 100 (1): 268–75. July 2002. doi:10.1182/blood.V100.1.268. PMID 12070036.
- "Association of NRAMP1 promoter gene polymorphism with the susceptibility and radiological severity of rheumatoid arthritis". Tissue Antigens 59 (4): 311–5. April 2002. doi:10.1034/j.1399-0039.2002.590410.x. PMID 12135431.
- "Association study of the NRAMP1 gene promoter polymorphism and early-onset type 1 diabetes". Immunogenetics 54 (4): 282–5. July 2002. doi:10.1007/s00251-002-0459-3. PMID 12136340.
- "Natural resistance-associated macrophage protein 1 polymorphisms are associated with microscopy-positive tuberculosis". The Journal of Infectious Diseases 186 (4): 517–21. August 2002. doi:10.1086/341775. PMID 12195379.
- "[Polymorphisms of the candidate genes for genetic susceptibility to tuberculosis in the Slavic population of Siberia: a pilot study]". Molekuliarnaia Biologiia 36 (5): 788–91. 2002. PMID 12391841.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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