Biology:Chloride potassium symporter 4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Potassium-chloride transporter, member 4 is a chloride potassium symporter protein. It is encoded by the gene SLC12A4.

See also

• Solute carrier family

Further reading

• "A tight cluster of five unrelated human genes on chromosome 16q22.1.". Hum. Mol. Genet. 2 (10): 1589–95. 1994. doi:10.1093/hmg/2.10.1589. PMID 8268911. 
• "Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family.". J. Biol. Chem. 271 (27): 16237–44. 1996. doi:10.1074/jbc.271.27.16237. PMID 8663127. 
• "Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.". Blood Cells Mol. Dis. 24 (1): 31–40. 1998. doi:10.1006/bcmd.1998.0168. PMID 9516379. 
• "Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation.". Am. J. Physiol. 277 (5 Pt 1): C899–912. 1999. doi:10.1152/ajpcell.1999.277.5.C899. PMID 10564083. 
• "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity.". J. Biol. Chem. 276 (45): 41870–8. 2001. doi:10.1074/jbc.M107155200. PMID 11551954. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl⁻ channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. 2003. doi:10.1152/ajpcell.00289.2002. PMID 12637262. 
• "KCl cotransport is an important modulator of human cervical cancer growth and invasion". J. Biol. Chem. 278 (41): 39941–50. 2003. doi:10.1074/jbc.M308232200. PMID 12902337. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Human potassium chloride cotransporter 1 (SLC12A4) promoter is regulated by AP-2 and contains a functional downstream promoter element". Blood 103 (11): 4302–9. 2004. doi:10.1182/blood-2003-01-0107. PMID 14976052. 
• "Oxygen dependence of K⁺–Cl⁻ cotransport in human red cell ghosts and sickle cells". Bioelectrochemistry 62 (2): 141–6. 2005. doi:10.1016/j.bioelechem.2003.07.005. PMID 15039017. 
• "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. 2004. doi:10.1074/jbc.M406706200. PMID 15262997. 
• "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.