Biology:SLC23A1
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Solute carrier family 23 member 1 is a protein that in humans is encoded by the SLC23A1 gene.[1][2][3]
Function
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2.[3]
See also
References
- ↑ "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1442 (2–3): 353–60. November 1998. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
- ↑ "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature 399 (6731): 70–5. May 1999. doi:10.1038/19986. PMID 10331392. Bibcode: 1999Natur.399...70T.
- ↑ 3.0 3.1 "Entrez Gene: SLC23A1 solute carrier family 23 (nucleobase transporters), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9963.
Further reading
- "Vitamin C transport systems of mammalian cells". Molecular Membrane Biology 18 (1): 87–95. 2001. doi:10.1080/09687680110033774. PMID 11396616.
- "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals". Genomics 59 (1): 18–23. July 1999. doi:10.1006/geno.1999.5847. PMID 10395795.
- "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function". Biochemical and Biophysical Research Communications 262 (3): 762–8. September 1999. doi:10.1006/bbrc.1999.1272. PMID 10471399.
- "Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant". Biochimica et Biophysica Acta (BBA) - Biomembranes 1461 (1): 1–9. November 1999. doi:10.1016/S0005-2736(99)00182-0. PMID 10556483.
- "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2". FEBS Letters 460 (3): 480–4. November 1999. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.
- "Human vitamin C (L-ascorbic acid) transporter SVCT1". Biochemical and Biophysical Research Communications 267 (2): 488–94. January 2000. doi:10.1006/bbrc.1999.1929. PMID 10631088.
- "Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2)". The Journal of Nutrition 131 (10): 2623–7. October 2001. doi:10.1093/jn/131.10.2623. PMID 11584081.
- "New view at C". Nature Medicine 8 (5): 445–6. May 2002. doi:10.1038/nm0502-445. PMID 11984580.
- "Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells". The Journal of Biological Chemistry 278 (11): 9035–41. March 2003. doi:10.1074/jbc.M205119200. PMID 12381735.
- "Regulation of the human vitamin C transporters expressed in COS-1 cells by protein kinase C [corrected]". American Journal of Physiology. Cell Physiology 283 (6): C1696-704. December 2002. doi:10.1152/ajpcell.00461.2001. PMID 12388072.
- "Polarized localization of vitamin C transporters, SVCT1 and SVCT2, in epithelial cells". Biochemical and Biophysical Research Communications 334 (1): 150–6. August 2005. doi:10.1016/j.bbrc.2005.06.069. PMID 15993839.
- "Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery". American Journal of Epidemiology 163 (3): 245–54. February 2006. doi:10.1093/aje/kwj035. PMID 16357110. https://zenodo.org/record/1234289.
- "Regulation of UVB-induced IL-8 and MCP-1 production in skin keratinocytes by increasing vitamin C uptake via the redistribution of SVCT-1 from the cytosol to the membrane". The Journal of Investigative Dermatology 127 (3): 698–706. March 2007. doi:10.1038/sj.jid.5700572. PMID 17008880.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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