Biology:Monocarboxylate transporter 3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene. MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

• Monocarboxylate transporter

Further reading

• "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics 60 (3): 366–70. 1999. doi:10.1006/geno.1999.5926. PMID 10493836. 
• "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. 2003. doi:10.1167/iovs.02-0287. PMID 12657613. 
• "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. 2005. doi:10.1074/jbc.M411950200. PMID 15917240. 
• "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul.. Current Topics in Cellular Regulation 18: 377–87. 1981. doi:10.1016/B978-0-12-152818-8.50028-1. ISBN 9780121528188. PMID 7273846. 
• "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. 2004. doi:10.1007/s00424-003-1067-2. PMID 12739169.