Biology:SLC22A2
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Short description: Protein-coding gene
 Generic protein structure example |
Solute carrier family 22 member 2 (also termed OCT2 or organic cation transporter-2[1]) is a protein that in humans is encoded by the SLC22A2 gene.[2][3]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption.[3]
See also
References
- ↑ "SLC22A2 solute carrier family 22 member 2 [Homo sapiens (human)] - Gene - NCBI". https://www.ncbi.nlm.nih.gov/gene/6582.
- ↑ "The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26". Cytogenet Cell Genet 79 (3–4): 198–200. Jun 1998. doi:10.1159/000134720. PMID 9605850.
- ↑ 3.0 3.1 "Entrez Gene: SLC22A2 solute carrier family 22 (organic cation transporter), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6582.
Further reading
- "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat.". J. Virol. 66 (1): 139–49. 1992. doi:10.1128/JVI.66.1.139-149.1992. PMID 1727476.
- "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor.". J. Virol. 67 (10): 6224–33. 1993. doi:10.1128/JVI.67.10.6224-6233.1993. PMID 7690421.
- "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor.". AIDS 10 (12): 1323–9. 1997. doi:10.1097/00002030-199610000-00003. PMID 8902060.
- "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat.". Biochem. J. 322 (1): 155–8. 1997. doi:10.1042/bj3220155. PMID 9078256.
- "Cloning and characterization of two human polyspecific organic cation transporters.". DNA Cell Biol. 16 (7): 871–81. 1997. doi:10.1089/dna.1997.16.871. PMID 9260930.
- "Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.". Mol. Pharmacol. 54 (2): 342–52. 1998. doi:10.1124/mol.54.2.342. PMID 9687576.
- "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27.". Genomics 55 (2): 209–18. 1999. doi:10.1006/geno.1998.5639. PMID 9933568.
- "Gene structures of the human non-neuronal monoamine transporters EMT and OCT2.". Hum. Genet. 106 (6): 627–35. 2000. doi:10.1007/s004390050035. PMID 10942111.
- "Properties and regulation of organic cation transport in freshly isolated human proximal tubules.". J. Biol. Chem. 276 (36): 33741–6. 2001. doi:10.1074/jbc.M104617200. PMID 11447227.
- "Regulation of BOB.1/OBF.1 stability by SIAH.". EMBO J. 20 (15): 4153–62. 2001. doi:10.1093/emboj/20.15.4153. PMID 11483518.
- "The human organic cation transporter (hOCT2) recognizes the degree of substrate ionization.". J. Biol. Chem. 277 (25): 22491–6. 2002. doi:10.1074/jbc.M203114200. PMID 11953440.
- "cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.". J. Am. Soc. Nephrol. 13 (7): 1703–10. 2002. doi:10.1097/01.ASN.0000019413.78751.46. PMID 12089365.
- "Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function.". Pharmacogenetics 12 (5): 395–405. 2003. doi:10.1097/00008571-200207000-00007. PMID 12142729.
- "Regulation of human organic cation transporter hOCT2 by PKA, PI3K, and calmodulin-dependent kinases.". Am. J. Physiol. Renal Physiol. 284 (2): F293–302. 2003. doi:10.1152/ajprenal.00251.2002. PMID 12388397.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Agmatine is efficiently transported by non-neuronal monoamine transporters extraneuronal monoamine transporter (EMT) and organic cation transporter 2 (OCT2).". J. Pharmacol. Exp. Ther. 304 (2): 810–7. 2003. doi:10.1124/jpet.102.044404. PMID 12538837.
- "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies.". Placenta 25 (6): 518–29. 2004. doi:10.1016/j.placenta.2003.10.017. PMID 15135235.
- "Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium.". Am. J. Respir. Cell Mol. Biol. 33 (1): 79–88. 2005. doi:10.1165/rcmb.2004-0363OC. PMID 15817714.
- "IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity.". Mol. Cell. Biol. 25 (15): 6496–508. 2005. doi:10.1128/MCB.25.15.6496-6508.2005. PMID 16024787.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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