Chemistry:Hydrocortisone aceponate
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| Clinical data | |
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| Trade names | Cortavance, others |
| AHFS/Drugs.com | Monograph |
| Routes of administration | Topical |
| Drug class | Corticosteroid |
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| Pharmacokinetic data | |
| Metabolism | Liver |
| Elimination half-life | 6-8 hours |
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| Chemical and physical data | |
| Formula | C26H36O7 |
| Molar mass | 460.567 g·mol−1 |
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Hydrocortisone aceponate is a veterinary corticosteroid that is used in form of creams for the treatment of various dermatoses (skin conditions).[6] It is an ester of hydrocortisone (cortisol) with acetic acid and propionic acid.
Medical uses
Hydrocortisone aceponate is typically used for skin conditions in veterinary practices for dogs. In this instance, it can be used on acute otitis externa,[7] a bacterial infection causing inflammation of the ear canal, as well as a treatment for itchy skin caused by allergies.[1] Additionally, hydrocortisone aceponate can be used to treat hormonal disorders and immune and allergic disorders.[8][unreliable medical source?] The main use for hydrocortisone aceponate is for atopic skin conditions and acute ear infections. It is shown to help with skin lesions and inflammation that respond to corticosteroids but may have been resistant to other treatments. It has been approved for veterinary use in the European Union.[7][1][2][4]
Adverse effects
Side effects include:[1]
- Inhibition of bone formation
- Suppression of calcium absorption
- Delayed wound healing
- Redness on skin
Chemistry
Hydrocortisone aceponate is a steroid which takes the form of a diester. The diester increases transmission of the medicine[1] through the skin and also increases the time that it remains in the affected area.[9]
Society and culture
Brand names
Cortavance is the brand name for a veterinary medication used to treat inflamed, itchy skin, typically caused by allergies.[1]
Easotic is the brand name for a veterinary combination medication used to treat acute ear infections in dogs.[7] It is composed of three active substances: hydrocortisone aceponate, miconazole nitrate and gentamicin. These are used in conjunction with hydrocortisone aceponate acts as an anti-inflammatory agent, miconazole nitrate has antifungal properties, and gentamicin is an antibiotic. The medication is used through ear drops and works to kill the foreign agent, prevent further spread, and mitigate symptoms.[7]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Cortavance EPAR". European Medicines Agency (EMA). 24 September 2021. https://www.ema.europa.eu/en/medicines/veterinary/EPAR/cortavance.
- ↑ 2.0 2.1 "Cortaderm EPAR". 17 June 2022. https://www.ema.europa.eu/en/medicines/veterinary/EPAR/cortaderm.
- ↑ "Alcort EPAR". 16 February 2024. https://www.ema.europa.eu/en/medicines/veterinary/EPAR/alcort.
- ↑ 4.0 4.1 "Alcort Product information". 9 April 2024. https://ec.europa.eu/health/documents/community-register/html/v306.htm.
- ↑ "Cortavance PI". 11 January 2007. https://ec.europa.eu/health/documents/community-register/html/v069.htm.
- ↑ "A study to evaluate the efficacy and safety of hydrocortisone aceponate 0.127% lipophilic cream in steroid responsive dermatoses in Indian patients". Indian Journal of Dermatology, Venereology and Leprology 76 (5): 591. 2010. doi:10.4103/0378-6323.69093. PMID 20827017.
- ↑ 7.0 7.1 7.2 7.3 "Easotic EPAR". 24 February 2021. https://www.ema.europa.eu/en/medicines/veterinary/EPAR/easotic.
- ↑ "Hydrocortisone aceponate". DrugBank. https://go.drugbank.com/drugs/DB14538.
- ↑ "Effect of fatty acid diesters on permeation of anti-inflammatory drugs through rat skin". Drug Development and Industrial Pharmacy 28 (10): 1285–1294. November 2002. doi:10.1081/ddc-120015362. PMID 12476874.
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