Chemistry:Ro 3-0422

From HandWiki
Ro 3-0422
Ro 3-0422.svg
Names
Preferred IUPAC name
3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate
Other names
3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
Identifiers
3D model (JSmol)
ChemSpider
Properties
C15H22NO8PS
Molar mass 407.37 g·mol−1
Hazards
Main hazards Extremely toxic
Lethal dose or concentration (LD, LC):
20 μg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous -1">50 is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]

See also

References

  1. HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base.". British Journal of Pharmacology and Chemotherapy 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMID 13172424. 
  2. Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.