Chemistry:Ro 3-0422
From HandWiki
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| Names | |
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| Preferred IUPAC name
3-[(Diethoxyphosphoryl)oxy]-1-methylquinolin-1-ium methyl sulfate | |
| Other names
3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
PubChem CID
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| Properties | |
| C15H22NO8PS | |
| Molar mass | 407.37 g·mol−1 |
| Hazards | |
| Main hazards | Extremely toxic |
| Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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20 μg/kg (mice, intravenous) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous -1">50 is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]
See also
References
- ↑ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base.". British Journal of Pharmacology and Chemotherapy 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMID 13172424.
- ↑ Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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