Chemistry:Minaprine
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Elimination half-life | 2-2.5 hours |
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| Formula | C17H22N4O |
| Molar mass | 298.390 g·mol−1 |
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Minaprine (INN, USAN, BAN; brand names Brantur, Cantor) is a monoamine oxidase inhibitor antidepressant drug[1] that was used in France for the treatment of depression until it was withdrawn from the market in 1996 because it caused convulsions.[2]
A study found that it acts as a reversible inhibitor of MAO-A (RIMA) in rats.[3] It has also been found to weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates.[4]
It has demonstrated significant antibiotic activity against M. chelonae and M. abscessus in tests with antibiotic resistant bacteria.[5]
Minaprine is a member of pyridazines, a secondary amine and a member of morpholines. It has a role as an antidepressant, a serotonin uptake inhibitor, a dopamine uptake inhibitor, a cholinergic drug and an antiparkinson drug.[6]
References
- ↑ "Minaprine - an overview | ScienceDirect Topics". https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/minaprine.
- ↑ "Evaluation of the Characteristics of Safety Withdrawal of Prescription Drugs from Worldwide Pharmaceutical Markets-1960 to 1999". Therapeutic Innovation & Regulatory Science 35 (1): 293–317. 1 January 2001. doi:10.1177/009286150103500134.
- ↑ "Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat". Biochemical Pharmacology 35 (6): 973–978. March 1986. doi:10.1016/0006-2952(86)90085-7. PMID 3954800.
- ↑ "Aminopyridazines as acetylcholinesterase inhibitors". Journal of Medicinal Chemistry 42 (4): 730–741. February 1999. doi:10.1021/jm981101z. PMID 10052979.
- ↑ "Identification of antimicrobial activity among FDA-approved drugs for combating Mycobacterium abscessus and Mycobacterium chelonae". The Journal of Antimicrobial Chemotherapy 66 (7): 1533–1536. July 2011. doi:10.1093/jac/dkr154. PMID 21486854.
- ↑ PubChem. "Minaprine" (in en). https://pubchem.ncbi.nlm.nih.gov/compound/4199.
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