Chemistry:Sulprostone
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| Formula | C23H31NO7S |
| Molar mass | 465.56 g·mol−1 |
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Sulprostone is an analogue of prostaglandin E2 (PGE2) that has oxytocic activity in assays of rat kidney cells and tissues.[1] There are four known receptors which mediate various but often different cellular and tissue responses to PGE2: prostaglandin EP1 receptor, prostaglandin EP2 receptor, prostaglandin EP3 receptor, and prostaglandin EP4 receptor. Sulprosotone binds to and activates the prostaglandin EP3 receptor with far greater efficacy than the other PGE2 receptors and also has the advantage of being relatively resistant, compared with PGE2, to becoming metabolically degraded. It is listed as a comparatively weak receptor agonist of the prostaglandin EP1 receptor. In all events, this as well as other potent synthetic EP3 receptor antagonists have the realized or potential ability to promote the beneficial effects of prostaglandin EP3 receptor activation.[2]
Sulprostone (as well as other prostanoids receptor agonists) is in use for inducting medical abortion and ending pregnancy after fetal death,[3] for the treatment of severe atonic postpartum hemorrhage after vaginal delivery,[4] and for removal of the placenta in patients with retained placenta.[5] Currently, sulprostone along with SC-46275, MB-28767, ONO-AE-248 and other EP3 receptor agonists are in development as drugs for the possible treatment of stomach ulcers in humans.[6]
References
- ↑ "The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho". Journal of Cell Science 116 (Pt 16): 3285–94. August 2003. doi:10.1242/jcs.00640. PMID 12829746. http://jcs.biologists.org/cgi/pmidlookup?view=long&pmid=12829746.
- ↑ "Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis". European Journal of Pharmacology 796: 7–19. 2017. doi:10.1016/j.ejphar.2016.12.004. PMID 27940058.
- ↑ "A randomized controlled trial of misoprostol and sulprostone to end pregnancy after fetal death". Obstetrics and Gynecology International 2009: 496320. 2009. doi:10.1155/2009/496320. PMID 19960062.
- ↑ "Prostaglandin E2 analogue sulprostone for treatment of atonic postpartum hemorrhage". Obstetrics and Gynecology 118 (2 Pt 1): 257–65. 2011. doi:10.1097/AOG.0b013e3182255335. PMID 21775840.
- ↑ "Prostaglandins for management of retained placenta". The Cochrane Database of Systematic Reviews (5): CD010312. 2014. doi:10.1002/14651858.CD010312.pub2. PMID 24833288.
- ↑ "Structural features of subtype-selective EP receptor modulators". Drug Discovery Today 22 (1): 57–71. 2017. doi:10.1016/j.drudis.2016.08.003. PMID 27506873.
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