Chemistry:Fenclofenac
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Short description: Withdrawn NSAID drug used in rheumatism
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| Preferred IUPAC name
[2-(2,4-Dichlorophenoxy)phenyl]acetic acid | |
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3D model (JSmol)
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PubChem CID
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| Properties | |
| C14H10Cl2O3 | |
| Molar mass | 297.1 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Fenclofenac is a nonsteroidal anti-inflammatory drug (NSAID) previously used in rheumatism. It has mild immunosuppressive effects[1] and may displace thyroid hormone from its binding protein.[2][3] It can also cause lichen planus.[4]
Due to its side effects it was withdrawn from the UK and US in the 1980s.
References
- ↑ "The effect of fenclofenac on the regeneration of lymphocytes in rats following total body irradiation". Int. J. Immunopharmacol. 15 (8): 865–9. November 1993. doi:10.1016/0192-0561(93)90003-h. PMID 7902830.
- ↑ "Fenclofenac and thyroid function tests". Br Med J 281 (6255): 1642. December 1980. doi:10.1136/bmj.281.6255.1642. PMID 7448557.
- ↑ "Prospective study of effect of fenclofenac on thyroid function tests". Br Med J 281 (6245): 911–2. October 1980. doi:10.1136/bmj.281.6245.911. PMID 7427506.
- ↑ "Oral mucosal lichenoid eruption due to fenclofenac". J Oral Med 39 (1): 39–40. 1984. PMID 6232357.
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