Chemistry:Flumizole

Flumizole
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole;
CAS Number	36740-73-5;
PubChem CID	37518;
ChemSpider	34419;
UNII	Y4YQF944N9;
KEGG	D04211;
ChEMBL	ChEMBL430150;
Chemical and physical data
Formula	C18H15F3N2O2
Molar mass	348.325 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2[nH]c(c(c1ccc(OC)cc1)n2)c3ccc(OC)cc3;
	InChI InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23); Key:OPYFPDBMMYUPME-UHFFFAOYSA-N;

Short description: NSAID anti-inflammatory compound

Flumizole is an antiinflammatory agent. More specifically, it is a nonsteroidal anti-inflammatory drug (NSAID) that acts via inhibition of the enzyme cyclooxygenase (COX).^[1]

References

↑ "Flumizole, a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences 64 (9): 1469–75. September 1975. doi:10.1002/jps.2600640909. PMID 810570.

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[1] "Flumizole, a new nonsteroidal anti-inflammatory agent". Journal of Pharmaceutical Sciences 64 (9): 1469–75. September 1975. doi:10.1002/jps.2600640909. PMID 810570.

[1]

v t e Nonsteroidal anti-inflammatory drugs (NSAIDs) (primarily M01A and M02A, also N02BA)
Pyrazolones / Pyrazolidines	Aminophenazone Ampyrone Azapropazone Clofezone Difenamizole Famprofazone Feprazone Kebuzone Metamizole Mofebutazone Morazone Nifenazone Oxyphenbutazone Phenazone Phenylbutazone Propyphenazone Sulfinpyrazone Suxibuzone^‡
Salicylates	Aspirin (acetylsalicylic acid)^# Aloxiprin Benorylate Carbasalate calcium Diflunisal Dipyrocetyl Ethenzamide Guacetisal Magnesium salicylate Methyl salicylate Salsalate Salicin Salicylamide Salicylic acid (salicylate) Sodium salicylate
Acetic acid derivatives and related substances	Aceclofenac Acemetacin Alclofenac Amfenac Bendazac Bromfenac Bumadizone Bufexamac Diclofenac Difenpiramide Etodolac Felbinac Fenclozic acid Fentiazac Indometacin Indometacin farnesil Isoxepac Ketorolac Lonazolac Oxametacin Prodolic acid Proglumetacin Sulindac Tiopinac Tolmetin Zomepirac^†
Oxicams	Ampiroxicam Droxicam Isoxicam Lornoxicam Meloxicam Piroxicam Tenoxicam
Propionic acid derivatives (profens)	Alminoprofen Benoxaprofen^† Carprofen^‡ Dexibuprofen Dexketoprofen Fenbufen Fenoprofen Flunoxaprofen Flurbiprofen Ibuprofen^# Ibuproxam Indoprofen^† Ketoprofen Loxoprofen Miroprofen Naproxen Oxaprozin Pirprofen Suprofen Tarenflurbil Tepoxalin^‡ Tiaprofenic acid Vedaprofen^‡ Zaltoprofen COX-inhibiting nitric oxide donator: Naproxcinod
N-Arylanthranilic acids (fenamates)	Azapropazone Clonixin Etofenamate Flufenamic acid Flunixin Meclofenamic acid Mefenamic acid Morniflumate Niflumic acid Tolfenamic acid Flutiazin
Coxibs	Apricoxib Celecoxib Cimicoxib^‡ Deracoxib^‡ Etoricoxib Firocoxib^‡ Lumiracoxib^† Mavacoxib^‡ Parecoxib Robenacoxib^‡ Rofecoxib^† Valdecoxib^†
Other	Aminopropionitrile Benzydamine Chondroitin sulfate Diacerein Fluproquazone Glucosamine Glycosaminoglycan Hyperforin Nabumetone Nimesulide Oxaceprol Proquazone Superoxide dismutase/Orgotein Tenidap
Items listed in bold indicate initially developed compounds of specific groups. ^#WHO-EM ^†Withdrawn drugs. ^‡Veterinary use medications.

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Clinical data

ATC code	none
Identifiers
IUPAC name 4,5-bis(4-methoxyphenyl)-2-(trifluoromethyl)-1H-imidazole
CAS Number	36740-73-5
PubChem CID	37518
ChemSpider	34419
UNII	Y4YQF944N9
KEGG	D04211
ChEMBL	ChEMBL430150
Chemical and physical data
Formula	C₁₈H₁₅F₃N₂O₂
Molar mass	348.325 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES FC(F)(F)c2[nH]c(c(c1ccc(OC)cc1)n2)c3ccc(OC)cc3
InChI InChI=1S/C18H15F3N2O2/c1-24-13-7-3-11(4-8-13)15-16(23-17(22-15)18(19,20)21)12-5-9-14(25-2)10-6-12/h3-10H,1-2H3,(H,22,23) Key:OPYFPDBMMYUPME-UHFFFAOYSA-N

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