Biology:SLC47A1
 Generic protein structure example |
Multidrug and toxin extrusion protein 1 (MATE1), also known as solute carrier family 47, member 1, is a protein that in humans is encoded by the SLC47A1 gene.[1][2] SLC47A1 belongs to the MATE (multidrug and toxic compound extrusion) family of transporters that are found in bacteria, archaea and eukaryotes.[3][4]
Gene
The SLC47A1 gene is located within the Smith-Magenis syndrome region on chromosome 17.[1]
Function
SLC47A1 is a member of the MATE family of transporters that excrete endogenous and exogenous toxic electrolytes through urine and bile.[2]
Discovery
The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents (norfloxacin, kanamycin, ethidium bromide etc.) and its homologue from E. coli were identified in 1998, which is the first of Solute carrier family 47 member.[3] NorM seems to function as drug/sodium antiporter which is the first example of Na+-coupled multidrug efflux transporter.[5] NorM is a prototype of a new transporter family and Brown et al. named it the multidrug and toxic compound extrusion family.[4] The X-ray structure of the transporter NorM was determined to 3.65 Å, revealing an outward-facing conformation with two portals open to the outer leaflet of the membrane and a unique topology of the predicted 12 transmembrane helices distinct from any other known multidrug resistance transporter.[6]
See also
- MATE (Multi antimicrobial extrusion protein or multidrug and toxic compound extrusion protein)
References
- ↑ 1.0 1.1 "Entrez Gene: FLJ10847 hypothetical protein FLJ10847". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55244.
- ↑ 2.0 2.1 "A human transporter protein that mediates the final excretion step for toxic organic cations". Proc. Natl. Acad. Sci. U.S.A. 102 (50): 17923–8. December 2005. doi:10.1073/pnas.0506483102. PMID 16330770.
- ↑ 3.0 3.1 "NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli". Antimicrob. Agents Chemother. 42 (7): 1778–82. July 1998. PMID 9661020.
- ↑ 4.0 4.1 "The multidrug efflux protein NorM is a prototype of a new family of transporters". Mol. Microbiol. 31 (1): 394–5. January 1999. doi:10.1046/j.1365-2958.1999.01162.x. PMID 9987140.
- ↑ "NorM of vibrio parahaemolyticus is an Na(+)-driven multidrug efflux pump". J. Bacteriol. 182 (23): 6694–7. December 2000. doi:10.1128/JB.182.23.6694-6697.2000. PMID 11073914.
- ↑ "Structure of a cation-bound multidrug and toxic compound extrusion transporter". Nature 467 (7318): 991–4. 2010. doi:10.1038/nature09408. PMID 20861838.
Further reading
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