Biology:Anion exchange transporter

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Anion exchange transporter is a protein that in humans is encoded by the SLC26A7 gene.[1][2][3][4]

Function

This gene is one member of a family of sulfate/anion transporter genes. Family members are well conserved in their genomic (number and size of exons) and protein (aa length among species) structures yet have markedly different tissue expression patterns. This gene has abundant and specific expression in the kidney. Splice variants that use both alternate transcription initiation and polyadenylation sites have been described for this gene.[4]

See also

References

  1. ↑ "Functional characterization of three novel tissue-specific anion exchangers SLC26A7, -A8, and -A9". The Journal of Biological Chemistry 277 (16): 14246–54. April 2002. doi:10.1074/jbc.M111802200. PMID 11834742. 
  2. ↑ "Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney". Genomics 79 (2): 249–56. February 2002. doi:10.1006/geno.2002.6689. PMID 11829495. 
  3. ↑ "Chloride/bicarbonate exchanger SLC26A7 is localized in endosomes in medullary collecting duct cells and is targeted to the basolateral membrane in hypertonicity and potassium depletion". Journal of the American Society of Nephrology 17 (4): 956–67. April 2006. doi:10.1681/ASN.2005111174. PMID 16524946. 
  4. ↑ 4.0 4.1 "Entrez Gene: SLC26A7 solute carrier family 26, member 7". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115111. 

Further reading

  • "Physiological roles and regulation of mammalian sulfate transporters". Physiological Reviews 81 (4): 1499–533. October 2001. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. 
  • "Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells". American Journal of Physiology. Gastrointestinal and Liver Physiology 284 (6): G1093–103. June 2003. doi:10.1152/ajpgi.00454.2002. PMID 12736153. 
  • "SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct". American Journal of Physiology. Renal Physiology 286 (1): F161–9. January 2004. doi:10.1152/ajprenal.00219.2003. PMID 12965893. 
  • "Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct". Journal of the American Society of Nephrology 15 (8): 2002–11. August 2004. doi:10.1097/01.ASN.0000135060.83250.07. PMID 15284286. 
  • "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Experimental Nephrology 101 (2): e50–8. 2006. doi:10.1159/000086345. PMID 15956810. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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