Biology:Zinc transporter ZIP1
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Short description: Protein found in humans
 Generic protein structure example |
Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[1][2][3]
The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[4]
See also
References
- ↑ "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics 62 (2): 272–80. Feb 2000. doi:10.1006/geno.1999.5993. PMID 10610721.
- ↑ "Functional expression of the human hZIP2 zinc transporter". J Biol Chem 275 (8): 5560–4. Mar 2000. doi:10.1074/jbc.275.8.5560. PMID 10681536.
- ↑ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27173.
- ↑ "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer 5: 17. 2006. doi:10.1186/1476-4598-5-17. PMID 16700911.
Further reading
- "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703–13. 2000. doi:10.1101/gr.10.5.703. PMID 10810093.
- "The human ZIP1 transporter mediates zinc uptake in human K562 erythroleukemia cells.". J. Biol. Chem. 276 (25): 22258–64. 2001. doi:10.1074/jbc.M101772200. PMID 11301334.
- "Differential subcellular localization of hZip1 in adherent and non-adherent cells.". FEBS Lett. 507 (3): 241–6. 2001. doi:10.1016/S0014-5793(01)02950-7. PMID 11696349.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human ZIP1 is a major zinc uptake transporter for the accumulation of zinc in prostate cells.". J. Inorg. Biochem. 96 (2–3): 435–42. 2003. doi:10.1016/S0162-0134(03)00249-6. PMID 12888280.
- "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". J. Biol. Chem. 278 (50): 50142–50. 2004. doi:10.1074/jbc.M304163200. PMID 14525987.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "hZIP1 zinc uptake transporter down regulation and zinc depletion in prostate cancer". Mol. Cancer 4: 32. 2006. doi:10.1186/1476-4598-4-32. PMID 16153295.
- "Overexpression of the ZIP1 zinc transporter induces an osteogenic phenotype in mesenchymal stem cells". Bone 38 (2): 181–98. 2006. doi:10.1016/j.bone.2005.08.010. PMID 16203195.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "A di-leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein". FEBS J. 274 (15): 3986–97. 2007. doi:10.1111/j.1742-4658.2007.05933.x. PMID 17635580.
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