Biology:SLC23A2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Solute carrier family 23 member 2 is a protein that in humans is encoded by the SLC23A2 gene.[1][2][3]
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1.[3]
See also
References
- ↑ "Molecular characterization of two novel transporters from human and mouse kidney and from LLC-PK1 cells reveals a novel conserved family that is homologous to bacterial and Aspergillus nucleobase transporters". Biochim Biophys Acta 1442 (2–3): 353–60. Dec 1998. doi:10.1016/S0167-4781(98)00151-1. PMID 9804989.
- ↑ "A family of mammalian Na+-dependent L-ascorbic acid transporters". Nature 399 (6731): 70–5. Jun 1999. doi:10.1038/19986. PMID 10331392. Bibcode: 1999Natur.399...70T.
- ↑ 3.0 3.1 "Entrez Gene: SLC23A2 solute carrier family 23 (nucleobase transporters), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9962.
Further reading
- "Vitamin C transport systems of mammalian cells.". Mol. Membr. Biol. 18 (1): 87–95. 2001. doi:10.1080/09687680110033774. PMID 11396616.
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. 2003. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. 1997. doi:10.1093/dnares/3.5.321. PMID 9039502.
- "A human nucleobase transporter-like cDNA (SLC23A1): member of a transporter family conserved from bacteria to mammals.". Genomics 59 (1): 18–23. 1999. doi:10.1006/geno.1999.5847. PMID 10395795.
- "Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.". Biochem. Biophys. Res. Commun. 262 (3): 762–8. 1999. doi:10.1006/bbrc.1999.1272. PMID 10471399.
- "Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2.". FEBS Lett. 460 (3): 480–4. 1999. doi:10.1016/S0014-5793(99)01393-9. PMID 10556521.
- "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells.". J. Biol. Chem. 275 (24): 18219–24. 2000. doi:10.1074/jbc.M909857199. PMID 10748165.
- "The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site.". J. Biol. Chem. 275 (41): 32331–7. 2000. doi:10.1074/jbc.M004795200. PMID 10915794.
- "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. 2002. doi:10.1038/414865a. PMID 11780052. Bibcode: 2001Natur.414..865D.
- Hediger MA (2002). "New view at C.". Nat. Med. 8 (5): 445–6. doi:10.1038/nm0502-445. PMID 11984580.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel.". Proc. Natl. Acad. Sci. U.S.A. 101 (10): 3691–6. 2004. doi:10.1073/pnas.0308393100. PMID 14993613. Bibcode: 2004PNAS..101.3691F.
- "A human sodium-dependent vitamin C transporter 2 isoform acts as a dominant-negative inhibitor of ascorbic acid transport.". Mol. Cell. Biol. 24 (8): 3150–6. 2004. doi:10.1128/MCB.24.8.3150-3156.2004. PMID 15060139.
- "Functional expression of sodium-dependent vitamin C transporter 2 in human endothelial cells.". J. Vasc. Res. 41 (4): 345–51. 2004. doi:10.1159/000080525. PMID 15340249.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.". Biochim. Biophys. Acta 1712 (2): 212–21. 2005. doi:10.1016/j.bbamem.2005.04.009. PMID 15921655.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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