Biology:Neutral amino acid transporter A

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Function

The transporter is responsible for transport of L-serine, L-alanine, L-cysteine, and L-threonine.

Pathology

Mutations of the gene cause a disease called spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM). This disorder is inherited in an autosomal recessive fashion.

Interactions

In melanocytic cells SLC1A4 gene expression may be regulated by MITF.

See also

• Glutamate transporter
• Solute carrier family

Further reading

• "Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family.". J. Biol. Chem. 268 (21): 15329–32. 1993. doi:10.1016/S0021-9258(18)82257-8. PMID 8101838. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Cloning and expression of a novel Na(+)-dependent neutral amino acid transporter structurally related to mammalian Na+/glutamate cotransporters.". J. Biol. Chem. 268 (21): 15351–5. 1993. doi:10.1016/S0021-9258(18)82263-3. PMID 8340364. 
• "Expressed human hippocampal ASCT1 amino acid transporter exhibits a pH-dependent change in substrate specificity.". Biochim. Biophys. Acta 1279 (2): 131–6. 1996. doi:10.1016/0005-2736(95)00259-6. PMID 8603078. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus.". J. Virol. 74 (17): 8085–93. 2000. doi:10.1128/JVI.74.17.8085-8093.2000. PMID 10933718. 
• "Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas.". Anticancer Res. 20 (5C): 3775–9. 2001. PMID 11268453. 
• "Active transport of alanine by the neutral amino-acid exchanger ASCT1.". Can. J. Physiol. Pharmacol. 79 (12): 1023–9. 2002. doi:10.1139/cjpp-79-12-1023. PMID 11824937. 
• "The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors.". J. Virol. 76 (13): 6442–52. 2002. doi:10.1128/JVI.76.13.6442-6452.2002. PMID 12050356. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "N-linked glycosylation and sequence changes in a critical negative control region of the ASCT1 and ASCT2 neutral amino acid transporters determine their retroviral receptor functions.". J. Virol. 77 (5): 2936–45. 2003. doi:10.1128/JVI.77.5.2936-2945.2003. PMID 12584318. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. 2005. doi:10.1038/nature03466. PMID 15815621. Bibcode: 2005Natur.434..724H. 
• "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.". J. Proteome Res. 5 (11): 3135–44. 2007. doi:10.1021/pr060363j. PMID 17081065. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.