Biology:Proton-coupled amino acid transporter 1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Proton-coupled amino acid transporter 1 is a protein that in humans is encoded by the SLC36A1 gene.[1][2][3]
This gene encodes a member of the eukaryote-specific amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.[3]
See also
References
- ↑ "Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters". J Biol Chem 277 (25): 22966–73. Jun 2002. doi:10.1074/jbc.M200374200. PMID 11959859.
- ↑ "Identification and characterization of a lysosomal transporter for small neutral amino acids". Proc Natl Acad Sci U S A 98 (13): 7206–11. Jun 2001. doi:10.1073/pnas.121183498. PMID 11390972. Bibcode: 2001PNAS...98.7206S.
- ↑ 3.0 3.1 "Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=206358.
Further reading
- "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. 2001. doi:10.1101/gr.143000. PMID 11076863.
- "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. 2001. doi:10.1101/gr.GR1547R. PMID 11230166.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. 2001. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2". J. Physiol. 546 (Pt 2): 349–61. 2003. doi:10.1113/jphysiol.2002.026500. PMID 12527723.
- "The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons". J. Neurosci. 23 (4): 1265–75. 2003. doi:10.1523/JNEUROSCI.23-04-01265.2003. PMID 12598615.
- "A cluster of proton/amino acid transporter genes in the human and mouse genomes". Genomics 82 (1): 47–56. 2004. doi:10.1016/S0888-7543(03)00099-5. PMID 12809675.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Organization and expression of the SLC36 cluster of amino acid transporter genes". Mamm. Genome 15 (2): 114–25. 2004. doi:10.1007/s00335-003-2319-3. PMID 15058382.
- "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat". Gastroenterology 127 (5): 1410–22. 2004. doi:10.1053/j.gastro.2004.08.017. PMID 15521011.
- "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)". J. Cell. Physiol. 204 (2): 604–13. 2005. doi:10.1002/jcp.20337. PMID 15754324.
- "Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1". Br. J. Pharmacol. 147 (3): 298–306. 2006. doi:10.1038/sj.bjp.0706557. PMID 16331283.
- "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2". J. Biol. Chem. 281 (52): 40114–23. 2007. doi:10.1074/jbc.M605407200. PMID 17050537.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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