Biology:Sodium–hydrogen antiporter 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.

Function

The Na⁺/H⁺ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II and CHP. It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.

Further reading

• "Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling". American Journal of Respiratory and Critical Care Medicine 177 (11): 1276–84. June 2008. doi:10.1164/rccm.200710-1522OC. PMID 18310478. 
• "Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells". American Journal of Physiology. Lung Cellular and Molecular Physiology 289 (5): L867–74. November 2005. doi:10.1152/ajplung.00455.2004. PMID 15964895. 
• "Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy". Circulation 115 (9): 1090–100. March 2007. doi:10.1161/CIRCULATIONAHA.106.626929. PMID 17339567. 
• "Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1". Current Opinion in Nephrology and Hypertension 16 (4): 365–72. July 2007. doi:10.1097/MNH.0b013e3281bd888d. PMID 17565280. 
• "Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger". The EMBO Journal 10 (8): 1957–67. August 1991. doi:10.1002/j.1460-2075.1991.tb07725.x. PMID 1712287. 
• "The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1". Human Genetics 86 (1): 79–83. November 1990. doi:10.1007/bf00205179. PMID 1979310. 
• "Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD". Science 247 (4943): 723–6. February 1990. doi:10.1126/science.2154036. PMID 2154036. Bibcode: 1990Sci...247..723S. 
• "Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter". Cell 56 (2): 271–80. January 1989. doi:10.1016/0092-8674(89)90901-X. PMID 2536298. 
• "The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization". Cytogenetics and Cell Genetics 48 (1): 6–8. 1988. doi:10.1159/000132575. PMID 2846238. 
• "The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain". Biochemistry 33 (34): 10463–9. August 1994. doi:10.1021/bi00200a030. PMID 8068684. 
• "Cloning and analysis of the human myocardial Na+/H+ exchanger". Molecular and Cellular Biochemistry 125 (2): 137–43. August 1993. doi:10.1007/BF00936442. PMID 8283968. 
• "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proceedings of the National Academy of Sciences of the United States of America 93 (22): 12631–6. October 1996. doi:10.1073/pnas.93.22.12631. PMID 8901634. Bibcode: 1996PNAS...9312631L. 
• "Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage". The American Journal of Physiology 275 (2): C431-9. August 1998. doi:10.1152/ajpcell.1998.275.2.C431. PMID 9688597. 
• "A novel topology model of the human Na(+)/H(+) exchanger isoform 1". The Journal of Biological Chemistry 275 (11): 7942–9. March 2000. doi:10.1074/jbc.275.11.7942. PMID 10713111. 
• "Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls". Cancer Genetics and Cytogenetics 120 (1): 37–43. July 2000. doi:10.1016/S0165-4608(99)00246-0. PMID 10913675. http://researchonline.rvc.ac.uk/id/eprint/6889/. 
• "Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation". Molecular Cell 6 (6): 1425–36. December 2000. doi:10.1016/S1097-2765(00)00139-8. PMID 11163215. 
• "14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange". The Journal of Biological Chemistry 276 (19): 15794–800. May 2001. doi:10.1074/jbc.M100410200. PMID 11279064. 
• "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". The Journal of Biological Chemistry 276 (20): 17367–72. May 2001. doi:10.1074/jbc.M100296200. PMID 11350981. 
• "The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor". The Journal of Biological Chemistry 276 (33): 31349–56. August 2001. doi:10.1074/jbc.M102679200. PMID 11369779. 
• "Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization". Molecular and Cellular Biology 21 (22): 7545–57. November 2001. doi:10.1128/MCB.21.22.7545-7557.2001. PMID 11604491. 
• "Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1". FEBS Letters 507 (3): 331–5. November 2001. doi:10.1016/S0014-5793(01)02986-6. PMID 11696366. 
• "Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells". FEBS Letters 512 (1–3): 52–8. February 2002. doi:10.1016/S0014-5793(01)03317-8. PMID 11852051. 
• "NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging". The Journal of Biological Chemistry 277 (49): 47399–406. December 2002. doi:10.1074/jbc.M204759200. PMID 12221084.