Biology:FGF14
 Generic protein structure example |
Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.[1][2][3]
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.[3]
FGF14 is mainly expressed in the central nervous system and is associated with neurodegenerative diseases such as spinocerebellar ataxia (SAC27). FGF14 deficiency also impairs the maturation of cells in the hippocampus, which is possibly related to the development of schizophrenia.[4]
Relationship with Alzheimer's disease
FGF14 levels are elevated in patients with Alzheimer's disease. FGF14 messenger RNA was also found to be upregulated in Alzheimer's patients, which suggests that it is involved in the pathogenesis of the disease, although the underlying mechanism is still unknown. Research is ongoing as to whether or not FGF14 could be used as a therapy against Alzheimer's disease as well as other neurodegenerative diseases, by promote neural proliferation and regulating the plasticity of the synapses.
References
- ↑ "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Proc Natl Acad Sci U S A 93 (18): 9850–7. Oct 1996. doi:10.1073/pnas.93.18.9850. PMID 8790420. Bibcode: 1996PNAS...93.9850S.
- ↑ "Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14". Neurobiol Dis 26 (1): 14–26. Mar 2007. doi:10.1016/j.nbd.2006.11.014. PMID 17236779.
- ↑ 3.0 3.1 "Entrez Gene: FGF14 fibroblast growth factor 14". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2259.
- ↑ Wang, Lusheng; Jing, Rongrong; Wang, Xing; Wang, Baohui; Guo, Keke; Zhao, Jungang; Gao, Shuang; Xu, Nuo et al. (June 2021). "A method for the expression of fibroblast growth factor 14 and assessment of its neuroprotective effect in an Alzheimer's disease model". Annals of Translational Medicine 9 (12): 994. doi:10.21037/atm-21-2492. ISSN 2305-5839. PMID 34277794.
Further reading
- Wang Q; Bardgett ME; Wong M et al. (2002). "Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14". Neuron 35 (1): 25–38. doi:10.1016/S0896-6273(02)00744-4. PMID 12123606.
- Chumakov I; Blumenfeld M; Guerassimenko O et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMID 12364586. Bibcode: 2002PNAS...9913675C.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- van Swieten JC; Brusse E; de Graaf BM et al. (2003). "A Mutation in the Fibroblast Growth Factor 14 Gene Is Associated with Autosomal Dominant Cerebral Ataxia". Am. J. Hum. Genet. 72 (1): 191–9. doi:10.1086/345488. PMID 12489043.
- Dunham A; Matthews LH; Burton J et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823. Bibcode: 2004Natur.428..522D.
- "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. 2004. doi:10.1074/jbc.M405795200. PMID 15199049.
- Stevanin G; Durr A; Dussert C et al. (2005). "Mutations in the FGF14 gene are not a major cause of spinocerebellar ataxia in Caucasians". Neurology 63 (5): 936. doi:10.1212/01.wnl.0000137020.30604.1e. PMID 15365159.
- Dalski A; Atici J; Kreuz FR et al. (2005). "Mutation analysis in the fibroblast growth factor 14 gene: frameshift mutation and polymorphisms in patients with inherited ataxias". Eur. J. Hum. Genet. 13 (1): 118–20. doi:10.1038/sj.ejhg.5201286. PMID 15470364.
- Lou JY; Laezza F; Gerber BR et al. (2006). "Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels". J. Physiol. 569 (Pt 1): 179–93. doi:10.1113/jphysiol.2005.097220. PMID 16166153.
- Brusse E; de Koning I; Maat-Kievit A et al. (2006). "Spinocerebellar ataxia associated with a mutation in the fibroblast growth factor 14 gene (SCA27): A new phenotype". Mov. Disord. 21 (3): 396–401. doi:10.1002/mds.20708. PMID 16211615.
- "Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (3): 395–6. 2007. doi:10.1002/ajmg.b.30472. PMID 17221845.
 |
