Biology:Long-chain fatty acid transport protein 4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Long-chain fatty acid transport protein 4 is a protein that in humans is encoded by the SLC27A4 gene.[1][2] This membrane protein is also called FATP4 or ACSVL5 (very long chain fatty acyl-CoA synthetase 5). The purified protein shows enzyme activity (EC 6.2.1.3), esterifying long and very long chain fatty acids with Coenzyme A.[3] It is debated whether it is also a fatty acid transporter at the plasma membrane.[4]
See also
References
- ↑ "Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1443 (3): 381–5. Dec 1998. doi:10.1016/s0167-4781(98)00231-0. PMID 9878842.
- ↑ "Entrez Gene: SLC27A4 solute carrier family 27 (fatty acid transporter), member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10999.
- ↑ "Enzymatic properties of purified murine fatty acid transport protein 4 and analysis of acyl-CoA synthetase activities in tissues from FATP4 null mice". The Journal of Biological Chemistry 280 (12): 11948–54. Mar 2005. doi:10.1074/jbc.M412629200. PMID 15653672.
- ↑ "Very-long-chain acyl-CoA synthetases". The Journal of Biological Chemistry 283 (4): 1773–7. Jan 2008. doi:10.1074/jbc.R700037200. PMID 18024425.
Further reading
- "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America 95 (15): 8625–9. Jul 1998. doi:10.1073/pnas.95.15.8625. PMID 9671728. Bibcode: 1998PNAS...95.8625H.
- "Identification of the major intestinal fatty acid transport protein". Molecular Cell 4 (3): 299–308. Sep 1999. doi:10.1016/S1097-2765(00)80332-9. PMID 10518211.
- "Genetic and structural evaluation of fatty acid transport protein-4 in relation to markers of the insulin resistance syndrome". The Journal of Clinical Endocrinology and Metabolism 89 (1): 392–9. Jan 2004. doi:10.1210/jc.2003-030682. PMID 14715877.
- "Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance". Diabetologia 47 (6): 1118–25. Jun 2004. doi:10.1007/s00125-004-1417-4. PMID 15168018.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Cellular uptake of fatty acids driven by the ER-localized acyl-CoA synthetase FATP4". Journal of Cell Science 119 (Pt 22): 4678–88. Nov 2006. doi:10.1242/jcs.03280. PMID 17062637.
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