Biology:Sodium-dependent neutral amino acid transporter B(0)AT2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Sodium-dependent neutral amino acid transporter B(0)AT2 is a protein that in humans is encoded by the SLC6A15 gene.[1]

Function

SLC6A15 shows structural characteristics of an Na+ and Cl-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites.[2]

Clinical relevance

Variants of this gene linked with depression are associated with reduced SLC6A15 expression in the human hippocampus, as well as decreased volume of this brain region.[3]

References

  1. "Entrez Gene: solute carrier family 6 (neutral amino acid transporter)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55117. 
  2. "Cloning and characterization of human NTT5 and v7-3: two orphan transporters of the Na+/Cl- -dependent neurotransmitter transporter gene family". Genomics 70 (2): 241–52. Dec 2000. doi:10.1006/geno.2000.6387. PMID 11112352. 
  3. "The neuronal transporter gene SLC6A15 confers risk to major depression". Neuron 70 (2): 252–65. Apr 2011. doi:10.1016/j.neuron.2011.04.005. PMID 21521612. 

Further reading