Biology:Sodium-dependent phosphate transport protein 2B
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.[1][2][3]
Clinical significance
Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.[4]
As of April 2023, upifitamab rilsodotin, an antibody-drug conjugate (ADC) targeting NaPi2b, is in Phase 3 clinical trials for recurrent platinum-sensitive ovarian cancer.[5]
See also
- Solute carrier family
- Pulmonary alveolar microlithiasis
References
- ↑ "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochemical and Biophysical Research Communications 258 (3): 578–582. May 1999. doi:10.1006/bbrc.1999.0666. PMID 10329428.
- ↑ "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics 62 (2): 281–284. December 1999. doi:10.1006/geno.1999.6009. PMID 10610722.
- ↑ "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10568.
- ↑ "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immunity 8: 3. February 2008. PMID 18251464.
- ↑ Clinical trial number NCT05329545 for "Upifitamab Rilsodotin Maintenance in Platinum-Sensitive Recurrent Ovarian Cancer (UP-NEXT)." at ClinicalTrials.gov
Further reading
- "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". American Journal of Physiology. Cell Physiology 280 (3): C628–C636. March 2001. doi:10.1152/ajpcell.2001.280.3.C628. PMID 11171583.
- "Growth-related renal type II Na/Pi cotransporter". The Journal of Biological Chemistry 277 (22): 19665–19672. May 2002. doi:10.1074/jbc.M200943200. PMID 11880379.
- "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". American Journal of Physiology. Gastrointestinal and Liver Physiology 288 (2): G175–G181. February 2005. doi:10.1152/ajpgi.00396.2004. PMID 15458926.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–126. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". American Journal of Human Genetics 79 (4): 650–656. October 2006. doi:10.1086/508263. PMID 16960801.
- "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". American Journal of Respiratory and Critical Care Medicine 175 (3): 263–268. February 2007. doi:10.1164/rccm.200609-1274OC. PMID 17095743.
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