Biology:Urea transporter 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Urea transporter 1 is a protein that in humans is encoded by the SLC14A1 gene.

Function

The SLC14A1 codes for a urea transporter (UTB) that is expressed in erythrocytes and kidney. SLC14A2 and SLC14A1 constitute solute carrier family 14. UTB proteins constitute the Kidd antigen system.

Further reading

• "The Kidd (JK) blood group locus assigned to chromosome 18 by close linkage to a DNA-RFLP.". Hum. Genet. 77 (3): 205–9. 1987. doi:10.1007/BF00284470. PMID 2890568. 
• "Cloning and functional expression of a urea transporter from human bone marrow cells.". J. Biol. Chem. 269 (50): 31649–52. 1995. doi:10.1016/S0021-9258(18)31744-7. PMID 7989337. 
• "RACH2, a novel human gene that complements a fission yeast cell cycle checkpoint mutation.". Mol. Biol. Cell 6 (10): 1411–21. 1996. doi:10.1091/mbc.6.10.1411. PMID 8573795. 
• "Molecular characterization of a new urea transporter in the human kidney.". FEBS Lett. 386 (2–3): 156–60. 1996. doi:10.1016/0014-5793(96)00425-5. PMID 8647271. https://hal.archives-ouvertes.fr/hal-02376236/file/Olive%CC%80s%20-%201996%20-%20Human%20kidney%20urea%20transporter.pdf. 
• "The molecular basis of the Kidd blood group polymorphism and its lack of association with type 1 diabetes susceptibility.". Hum. Mol. Genet. 6 (7): 1017–20. 1997. doi:10.1093/hmg/6.7.1017. PMID 9215669. 
• "Characterization of the gene encoding the human Kidd blood group/urea transporter protein. Evidence for splice site mutations in Jknull individuals.". J. Biol. Chem. 273 (21): 12973–80. 1998. doi:10.1074/jbc.273.21.12973. PMID 9582331. 
• "Genomic typing of the Kidd blood group locus by a single-tube allele-specific primer PCR technique.". Br. J. Haematol. 102 (4): 1010–4. 1998. doi:10.1046/j.1365-2141.1998.00874.x. PMID 9734652. 
• "At physiological expression levels the Kidd blood group/urea transporter protein is not a water channel.". J. Biol. Chem. 274 (42): 30228–35. 1999. doi:10.1074/jbc.274.42.30228. PMID 10514515. 
• "Genomic characterization of the kidd blood group gene:different molecular basis of the Jk(a-b-) phenotype in Polynesians and Finns.". Transfusion 40 (1): 69–74. 2000. doi:10.1046/j.1537-2995.2000.40010069.x. PMID 10644814. 
• "Molecular heterogeneity of the Jk(null) phenotype: expression analysis of the Jk(S291P) mutation found in Finns.". Blood 96 (4): 1566–73. 2000. doi:10.1182/blood.V96.4.1566. PMID 10942407. 
• "Partial deletion in the JK locus causing a Jk(null) phenotype.". Blood 99 (3): 1079–81. 2002. doi:10.1182/blood.V99.3.1079. PMID 11807016. 
• "Novel alleles at the JK blood group locus explain the absence of the erythrocyte urea transporter in European families.". Br. J. Haematol. 116 (2): 445–53. 2002. doi:10.1046/j.1365-2141.2002.03238.x. PMID 11841450. 
• "Antigenic and functional properties of the human red blood cell urea transporter hUT-B1.". J. Biol. Chem. 277 (37): 34101–8. 2002. doi:10.1074/jbc.M205073200. PMID 12093813. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon.". Am. J. Physiol., Cell Physiol. 287 (1): C30–5. 2004. doi:10.1152/ajpcell.00443.2003. PMID 14985236.